| About the author: |
O. O. Yakimenko, K. S. Chernyshova, V. M. Bondar, O. I. Tiron, Ie. A. Maznichenko |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The total of 123 young hypertensive patients were examined with normal weight, overweight and obesity (average age 32.83±0.58 years old). They were performed genetic analysis of endothelial NO-synthase gene polymorphisms – T(-786)C and G894T as genetic markers of endothelial dysfunction. The frequency dominance of G894T polymorphism “pathological” genotypes was revealed in all groups. Cases of combination of T(-786)C and G894T polymorphisms were significantly more frequent in young hypertensive patients with concomitant obesity. Homocysteinemia and daily microalbuminuria were checked as biochemical markers of endothelial dysfunction. These markers were more expressed in concomitant overweight and obesity compared with normal-weight young hypertensive patients. A significant positive correlation was revealed between the levels of homocysteinemia and microalbuminuria, and also between these markers and the body mass index. It was found that “pathological” genotypes of both studied eNOS gene polymorphisms are associated with a higher level of homocysteinemia and daily microalbuminuria. arterial hypertension, obesity, homocysteine, microalbuminuria |
| Tags |
endothelial NO synthase gene, polymorphism, homocysteinemia, microalbuminuria, arterial hypertension, obesity |
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| Publication of the article |
«World of Medicine and Biology» №4(78), 2021 year, 177-182 pages, index UDK 616.12-008.331.1-06-056.257-053.81-074/-078 |
| DOI |
10.26724/2079-8334-2021-4-78-177-182 |
