| About the author: |
A. V. Artemchuk, O. V. Savychuk, O. I. Ostapko, V. A. Krychkevych, O. I. Koval |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Diabetes mellitus is one of the most common endocrine diseases, which prevalence is growing rapidly every year. The main pathogenetic factor of diabetes mellitus is persistent hyperglycemia and changes in the vascular walls of the microcirculatory bed. This leads to morphofunctional changes in the vascular wall, impaired permeability and trophism with progressive deterioration of hemodynamics and profound dystrophic changes, and, consequently, the inflammatory process's development. In the microcirculatory bed of the periodontium in patients with diabetes mellitus, there are pronounced changes in biochemical parameters of the blood and disturbed homeostasis, reduced resistance of periodontal tissues. This leads to increased exposure to periodontal pathogenic microflora, disrupts the integrity of the tooth-epithelial attachment, resorption of the cortical plate and the interdental septum, leading to tooth loss. The study of morphological changes in periodontal tissues of white Wistar rats in the conditions of experimental modelling of Type 2 diabetes mellitus is of great informational importance. This contributes to the development of measures aimed at preventing, early diagnosis, and effective treatment of periodontal diseases in patients with type 2 diabetes, especially in children and adolescents. Histological examination of morphological changes in periodontal tissues obtained with a microscope may be of practical use in future studies, serve to develop diagnostic, therapeutic and preventive measures for periodontal disease in children and adolescents with type 2 diabetes mellitus. |
| Tags |
diabetes mellitus, streptozotocin, pathogenetic mechanisms, periodontium, periodontal changes |
| Bibliography |
- Abramov AV, Hanchev KS. Kilkisnyy analiz proliferatyvnoyi aktyvnosti tkanyn parodontu shchuriv pislya ekstraktsiyi zuba na foni eksperymentalnoho tsukrovoho diabetu. Klinichna ta eksperymentalna patolohiya 2019. Т.18, №1 (67): 10–15. doi: 10.24061/1727-4338.XVІІI.1.67.2019.199. [in Ukrainian]
- Balitska OYu, Bondarenko YuI, Habor HH. Aktyvnist humoralnoyi lanky adaptyvnoyi imunnoyi systemy u khvorykh na khronichnyy heneralizovanyy parodontyt i tsukrovyy diabet 2 typu. Klinichna stomatolohiya.2019. No 3: 62–65. doi: 2415-8798.2018.3.9402. [in Ukrainian]
- Vynohradova OM, Shkrebnyuk RYu. Dyferentsiyni zminy likuvannya zakhvoryuvan tkanyn parodonta na tli tsukrovoho diabetu. Klinichna ta eksperymentalna patolohiya 2015; 1 (51) 14: 205–208. [in Ukrainian]
- Hrytsyuk MI, Boychuk TM, Petryshen OI. Porivnyalna kharakterystyka eksperymentalnykh modeley tsukrovoho diabetu. ISSN 2079-8334. Svit medytsyny ta biolohiyi. 2014. № 2(44): 199–203. [in Ukrainian]
- Dobrelya NV, Parshykov OV, Boytsova LV, Khromov OS. Modelyuvannya tsukrovoho diabetu II typu. Farmakolohiya ta likarska toksykolohiya. 2019; 1,13: 42–50. [in Ukrainian]
- Skiba AV, Reshetnikova OS, Morozov SA, Smirnov SN. Patomorfologicheskiye osobennosti slizistoy obolochki shcheki, yazyka krys pri ekspermentalnom sakharnom diabete 2 tipa. Innovatsii v stomatologii. 2015; 3: 7–26. [in Russian]
- Smolyar NI, Pryshlyak VYe. Patohenetychni aspekty vynyknennya i poshyrennya diabetu ta yoho uskladnennya v ditey. Ukrayinskyy stomatolohichnyy almanakh. 2013; 4: 79–81. [in Ukrainian]
- Spasov AA, Voronkova MP, Snigur GL. Eksperimentalnaya model sakharnogo diabeta 2 tipa. Biomeditsina. 2011; 3: 2–18. [in Russian]
- Tkachuk OV, Halahdyna AA, Tkachuk SS, Myslytskyy VF. Patobiokhimichni ta patomorfolohichni ekvivalenty urazhennya parodonta ta slyzovoyi obolonky rotovoyi porozhnyny pry tsukrovomu diabeti. Naukovi ohlyady 2014; 3 (49) 13: 231–235. doi: https://doi.org/10.24061/1727-4338.XIII.3.49.2014.46 [in Ukrainian]
- Yakymets MN, Bezkorovaynaya MZ, Pynda MYa. Porivnyalnyy analiz stanu tkanyn parodonta u khvorykh na tsukrovyy diabet 1 ta 2 typiv. Klinichna stomatolohiya. 2014; 2: 31–37. ISSN 2311-9624 [in Ukrainian]
- Bowe JE, Franklin ZJ, Hauge-Evans AC.Assessing glucose homeostasis in rodent models/Journal of Endocrinology. 2014; 222: 13–25. doi: 10.17535/crorr.2020.0010.
- King AJ. The use of animal models in diabetes research. King AJ, Pharmacol Br. J.. 2012; 166(3): 877–894. doi: 10.1111/j.1476-5381.2012.01911.x.
- Radha Sharma, Vivek Dave, Swapnil Sharma. Sharma Swapnil Experimental Models of Diabetes: A Comprehensive Review. International Journal of Advances in Pharmaceutical Sciences. – 2013. – No. 4. – P. 1-8.
- Rees D. A. Animal models of diabetes mellitus. D.A.Rees, J.C. Alcolado. Diabet. Med. – 2005. – Vol.22(4). – P.359-370. doi: https://doi.org/10.1111/j.1464-5491.2005.01499.x
- Srinivasan K. Animal models in type 2 diabetes research: an overview K. Srinivasan, P.Ramarao. Indian J. Med. Res. – 2007. – No.125. – P. 451-472. doi: 10.1590/0001-3765202020191340.
|
| Publication of the article |
«World of Medicine and Biology» №4(78), 2021 year, 190-195 pages, index UDK 616.314.17/.18-002-018:616.37-008.64]-092.9 |
| DOI |
10.26724/2079-8334-2021-4-78-190-195 |
