| About the author: |
L. S. Kravchenko, O. L. Appelhans, A. E. Poliakov, О. V. Pasechnyk, I. Yu. Borysiuk, O. V. Honcharenko, Ya. I. Ivanova |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The efficacy of the treatment-and-prophylactic complex, which includes phytopreparation based on the dihydroquercetin bioflavonoid – a natural capillary protector, an antioxidant that by its pharmacological action belongs to the group of angioprotectors and a microcirculation corrector, used per os, in combination with local therapy of periodontal tissues with a new dental elixir based on propolis and biologically active substances of plant origin adaptogens with ultraphonophoresis was determined in experiment on 48 white male Wistar rats, aged 2–3 months, weighing (238±10) g. Under induced metabolic syndrome in rats, the use of the treatment-and-prophylactic complex neutralized the negative effects of the components of the pathological condition in the form of improved metabolism with normalization of glucose, triglycerides, cholesterol, anti-inflammatory interleukins level in the blood serum, improved liver condition and periodontal tissues. The treatment-and-prophylactic complex on the background of MS simulation rendered a periodontal-protective effect and had positive influence on systems of antioxidant defence and nonspecific resistance both at the systemic level and in the periodontal tissues. |
| Tags |
metabolic syndrome, prevention, inflammation, antioxidant protection, periodontium |
| Bibliography |
- Birulina IuG, Ivanov VV, Buyko IeIe, Bykov VV. Experimentalnaya model metabolicheskogo sindroma u krys na osnove vysoko zhirovoy i vysokouglevodnoy diety. Biulleten sibirskoy meditsyny. 2020;19(4):14–20 doi:10/20538|1682-0363-2020-4-14-20 [in Russian]
- Hrygorieva OA, Korotchyk GV. Morfometrychni, instrumentalni ta laboratorni pokaznyky samok shchuriv z eksperymentalnym metabolichnym syndromom. Zdobutky klinichnoyi i eksperimentalnoyi medytsyny 2020;3:20–25 doi: 10/11603|18110363-2471.2020/v. I 3. 11578 [in Ukrainian]
- Goryachkovskiy AM. Klinicheskaya biokhimiya v laboratornoy diagnostike. Odessa, 2005. 616 p. [in Russian]
- Kravchenko LS, Appelkhans OL, Ivanova YaI, Goncharenko OV (patentee) Patent Ukrainy 122996 MPK (2021.01) А61К8/19, А61К35/644. Zubnyi eliksyr dlya mistsevoyi profilaktyky i likuvannya zapalnykh protsesiv slyzovoyi obolonky porozhnyny rota ta tkanyn parodonta. а202002339 of 10.04.2020; publ. 27.01.2021, bul. No.4. [in Ukrainian]
- Levitskiy AP, Denga OV, Makarenko OA, Demyanenko SA, Rossakhanova LN, Knava OE. Biokhimicheskie markery vospaleniya tkaney rotovoy polosti. Metodicheskie rekomendatsii. Odessa: KP “OGT” 2010. 16 p. [in Russian]
- Makarova MN, Makarov VG. Diet-indutsirovannye modeli metabolicheskikh narusheniy. Eksperimental'nyy metabolicheskiy sindrom. Laboratornye zhivotnye dlia nauchnykh issledovaniy 2018;1:79–91 doi:10.29926/2618723X-2018-01-08 [in Russian]
- Meladze IN. Vospalitelno-destruktivnye izmeneniia v tkaniakh parodonta krys pri eksperimentalnom metabolicheskom sindrome i puti ikh ustraneniya. Sovremennaya stomatologiya 2016;4:73–75 [in Russian]
- Petruкhina NB, Zorina OA, Shih EV, Kartysheva EV, Kudriavtsev AV. Izmenenie provospolitelnyкh tsitokinov u patsientov s khronicheskim parodontitom na fone metabolicheskogo sindroma v zavisimosti ot pola i vozrasta. Stomatologiya 2018;6:38–45 [in Russian]
- Pindus TA, Den'ga AIe, Tkachenko EK. Sostoianie tkaney rotovoy polosti krys v uslovijakh modelirovaniya metabolicheskogo sindroma. Bukovinskiy medychnyy vіsnyk 2017;21;4(84):89–98. Doi:10.24061/2413-0737.XXI.4.84.2017.128 [in Russian]
- Garlet GP, Andreza MF Aranha, Silveira Elcia M, Andreia Espindola Vieira, Queiroz-Junior Celso M et al. The Role of Chemokines and Cytokines in the Pathogenesis of Periodontal and Periapical Lesions: Current Concepts, Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases, Mahin Khatami, IntechOpen, (March 9th 2012). Doi: 10.5772/27252. Available from: https://www.intechopen.com/chapters/31361.
- Kaur JA. A comprehensive review on metabolic syndrome. Cardiol Res Pract. 2014; 943162, doi:10.1155/2014/943162.
- Mirhafez SR, Pasdar A, Avan A. Esmaily H. Moezzi A, Mohebati M et al. Cytokine and growth factor profiling in patients with the metabolic syndrome. Br. J. Nutr. 2015; 113(12):1911–9. doi:10.1017/S0007114515001038.
- SaKlayen MG The global epidemic of the metabolic syndrome. Curr. Hypertens Rep. 2018; 20(2):12. doi:10.1007/s11906-018-0812-z.
- Shalitin S, Battelino T, Moreno LA, Koletzko B, Shamir R, Turck D et al. (Eds) Obesity, metabolic syndrome and nutrition. Nutrition and growth. World, Rev. Nutr. Diet. Basel, Karger. 2019; 119:13–42 doi: 10.1159/000494306.
- Watanable K, Cho YD. Periodontal disease and metabolic syndrome: a qualitative critical review of their association Arch Oral Biol. 2014 Aug; 59(8): 855–70. Doi: 10.1016/j. archorablio.2014.05.003.
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| Publication of the article |
«World of Medicine and Biology» №4(78), 2021 year, 219-224 pages, index UDK 618.311.2:616.314.16/17-08:615.27:616-008.9 |
| DOI |
10.26724/2079-8334-2021-4-78-219-224 |
