| About the author: |
A. E. Dienga, N. V. Malekh, T. G. Verbytska, P. D. Rozhko, S. A. Shnaider |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The study is dedicated to searching for genetic factors that determine the predisposition to children's hypertrophic and catarrhal forms of gingivitis. The study involved children with hypertrophic gingivitis (12 patients) and chronic catarrhal gingivitis (16 patients). Because of the study, it was found that hypertrophic gingivitis and chronic catarrhal gingivitis differed significantly in the distribution of polymorphism genotypes TNFRSF1B, MMP1B and TGFB1 in examined patients. No difference was found between the groups by rs1800629 TNF-alpha-308G>A, rs1800795 IL6-174G>C, rs3024491 IL10-1082G>A and rs1800012 COL1A1 IVS1 2046G>T polymorphisms. The results obtained, in our opinion, should be taken into account in the development of treatment and prevention measures to support the dental treatment of children with hypertrophic gingivitis. |
| Tags |
children, periodontal tissue diseases, gene polymorphisms, buccal epithelium, polymerase chain reaction |
| Bibliography |
- Ahmed BT, Saeed MY, Noori SH, Amin DM. TGF-β1 Gene Polymorphism and Its Correlation with Serum Level of TGF-β1 in Psoriasis Vulgaris Among Iraqi People. Clin Cosmet Investig Dermatol. 2020;13:889–896. doi: 10.2147/CCID.S281585.
- Avetikov DS, Buchanhenko OP, Shlykova OA, Izmajlova OV, Lokes KP, Klitynska OV, et al. Presence of Type 1 Collagen Alpha-2 (COL1A2) (rs42524) Gene Polymorphism and Scar Tissue Formation in Different Areas of Head and Neck. Pesquisa Brasileira em Odontopediatria e Clínica Integrada. 2020; 20(e4422):1–6. doi: 10.1590/pboci.2020.031.
- Brodzikowska A, Górska R, Kowalski J. Interleukin-1 Genotype in Periodontitis. Arch Immunol Ther Exp (Warsz). 2019;67(6):367–373. doi: 10.1007/s00005-019-00555-4.
- Ding C, Ji X, Chen X, Xu Y, Zhong L. TNF-α gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies. J Clin Periodontol. 2014; 41(8):748–759. doi: 10.1111/jcpe.12279.
- Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998 Oct 1; 102(7):1369–1376. doi: 10.1172/JCI2629.
- Juarez I, Gutierrez A, Vaquero-Yuste C, Molanes-López EM, López A, Lasa I, et al. TGFB1 polymorphisms and TGF-β1 plasma levels identify gastric adenocarcinoma patients with lower survival rate and disseminated disease. J Cell Mol Med. 2021; 25(2):774–783. doi:10.1111/jcmm.16131.
- Kassebaum NJ, Smith AGC, Bernabé E, Fleming TD, Reynolds AE, Vos T, et al. GBD 2015 Oral Health Collaborators. Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990-2015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors. J Dent Res. 2017; 96(4):380–387. doi: 10.1177/0022034517693566.
- Kiliś-Pstrusińska K, Mastalerz-Migas A, Zwolińska D, Grzeszczak W, Zachwieja K, Zachwieja J, et al. The rs1800471 Polymorphism of TGFB1 Gene, Serum TGF-Beta1 Level and Chronic Kidney Disease Progression. Adv Exp Med Biol. 2015; 833:37–46. doi: 10.1007/5584_2014_80.
- Kim JJ, Kim CJ, Camargo PM. Salivary biomarkers in the diagnosis of periodontal diseases. J Calif Dent Assoc. 2013; 41(2):119–124.
- Nabrdalik K, Gumprecht J, Adamczyk P, Górczyńska-Kosiorz S, Zywiec J, Grzeszczak W. Association of rs1800471 polymorphism of TGFB1 gene with chronic kidney disease occurrence and progression and hypertension appearance. Arch Med Sci. 2013; 9(2):230–237. doi: 10.5114/aoms.2013.34418.
- Scapoli L, Girardi A, Palmieri A, Martinelli M, Cura F, Lauritano D, et al. Interleukin-6 gene polymorphism modulates the risk of periodontal diseases. J Biol Regul Homeost Agents. 2015; 29(3):111–116.
- Sean Walsh P, Metzger DA, Higuchi R. Chelex 100 as a Medium for Simple Extraction of DNA for PCR-Based Typing from Forensic Material. BioTechniques, 2013; 54(3):134–139. doi: 10.2144/000114018.
- Sennikov SV, Vasilyev FF, Lopatnikova JA, Shkaruba NS, Silkov AN. Polymorphisms in the tumor necrosis factor receptor genes affect the expression levels of membrane-bound type I and type II receptors. Mediators Inflamm. 2014; 2014:745909. doi: 10.1155/2014/745909.
- Trombelli L, Farina R, Silva CO, Tatakis DN. Plaque-induced gingivitis: Case definition and diagnostic considerations. J Periodontol. 2018; 89(1): S46–S73 doi: 10.1111/jcpe.12939.
- Vanamee ÉS, Faustman DL. TNFR2: A Novel Target for Cancer Immunotherapy. Trends Mol Med. 2017; 23(11):1037–1046. doi: 10.1016/j.molmed.2017.09.007.
|
| Publication of the article |
«World of Medicine and Biology» №1(79), 2022 year, 054-058 pages, index UDK (616–053.5+616.311.2–002):575 |
| DOI |
10.26724/2079-8334-2022-1-79-54-58 |
