| About the author: |
M. E. Zapolskiy, M. М. Lebediuk, M. O. Dudchenko, N. В. Prokofyeva, К. V. Vasylyeva, A. V. Dobrovolska, Yu. V. Tepliuk |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
When examining 87 patients with moderate and severe forms of atopic dermatitis aged 16 to 49 years, trigger factors in various clinical forms of atopic dermatitis were analysed. It was revealed that diamine oxidase deficiency and trigger factors aggravate the course of atopic dermatitis. Diamine oxidase deficiency in atopic dermatitis was combined with insignificant dynamics in relation to IgE and slow regression of the SCORAD index. It was revealed that the degree of influence of diamine oxidase on the course of atopic dermatitis (especially at SCORAD≥25) makes it possible to identify a group of patients who need additional regulation of tissue histamine conversion and active blocking of exogenous histamine liberators. A low level of diamine oxidase activity correlated with a slow regression of clinical symptoms of dermatosis, including more persistent pruritus, deterioration of the general condition, insomnia, irritability, and psycho-emotional asthenia. |
| Tags |
aetiology of atopic dermatitis, diamine oxidase, clinical forms of atopic dermatitis, SCORAD index |
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| Publication of the article |
«World of Medicine and Biology» №1(79), 2022 year, 068-073 pages, index UDK 616.5.1-002:615.26 |
| DOI |
10.26724/2079-8334-2022-1-79-68-73 |
