About the author: |
N. R. Matkovska, N. H. Virstiuk, U. V. Balan, I. O. Kostitska, M. S. Voloshynovych, N. V. Chaplynska, V. T. Rudnyk |
Heading |
CLINICAL MEDICINE |
Type of article |
Scentific article |
Annotation |
The purpose of the study was to clarify the features of course of alcoholic liver disease at the stage of cirrhosis in combination with fatty liver disease. Clinical, laboratory and instrumental examinations were performed for 204 patients with alcoholic liver cirrhosis. It was found that all patients systematically took toxic doses of alcohol that caused clinical manifestations of the disease and a violation of the functional state of the liver. Somatometric indices significantly differed in all patients depending on the degree of compensation. The thickness of the skin and fat fold are reliable indicators that reflect the state of the fat depot of the body; the circumference of shoulder muscles is a reliable indicator of the reduction of the somatic protein pool, accompanied by a decrease in the synthetic function of the liver, especially in patients associated with fatty liver disease. Therefore, when examining patients with alcoholic liver cirrhosis, along with general clinical and laboratory-instrumental examinations, it is recommended to evaluation the trophological status to predict the course of liver cirrhosis. |
Tags |
alcoholic liver disease; fatty liver disease; cirrhosis; functional liver tests; nutritional status |
Bibliography |
- Bischoff SC, Bernal W, Dasarathy S, Merli M, Plank LD, Schütz T, et al. Praktychni nastanovy Yevropeyskoi asotsiatsii klinichnoho kharchuvannia ta metabolizmu (ESPEN). Klinichne kharchuvannia pry zakhvoriuvanniakh pechinky. Suchasna hastroenterolohiia. 2021; 2 (118): 28–40. doi: http://doi.org/10.30978/MG-2021-2-28[in Ukrainian]
- Mykhailovska NS, Miniailenko LI, Serhieieva LN, Oliinyk TV. Markery rannyoyi diahnostyky steatozu pechinky u khvorykh na ishemichnu khvorobu sertsia. Bukovynskyi medychnyi visnyk. 2018; 2 (86): 47–54. doi: 10.24061/2413-0737 [in Ukrainian]
- Parkheta LV. Medyko-demohrafichni pokaznyky ta yikh vplyv na rozvytok dobrovilnoho medychnoho strakhuvannia v Ukraini. Efektyvna ekonomika [Internet]. 2018 Jan [cited 2021 Jan. 17]; Available from: http://www.economy.nayka.com.ua/?op=1&z=6084 [in Ukrainian]
- Cerović I, Mladenović D, Ješić R, Naumović T, Branković M, Vučević D, et al. Alcoholic liver disease/nonalcoholic fatty liver disease index. European Journal of Gastroenterology & Hepatology. 2013; 25(8): 899–904. doi:10.1097/meg.0b013e32835f0786
- Finck BN. Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis. Diabetes. 2018; 67(12): 2485–2493. doi: 0.2337/dbi18-0024
- Jensen T, Abdelmalek M, Sullivan S, Nadeau K, Green M, Roncal C, et al. Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. Journal of hepatology. 2018; 68: 1063–1075. doi: 10.1016/j.jhep.2018.01.019
- Paik YH, Seo YS, Kim MY, Park JY, Suk KT, Song DS, et al The Korean Association for the Study of the Liver clinical practice guidelines for liver cirrhosis: Ascites and related complications. Clinical and Molecular Hepatology. 2018; 24(3): 230–277. doi: 10.3350/cmh.2018.1005
- Papatheodoridi M, Cholongitas E. Diagnosis of non-alcoholic fatty liver disease: current concepts. Current Pharmaceutical Design. 2018; 38(24): 4574–4586. doi: 10.2174/1381612825666190117102111
- Santos RD, Valenti L, Romeo S. Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps. Atherosclerosis. 2019; 282: 110–120. doi: 10.1016/j.atherosclerosis.2019.01.029
- Sporea I, Popescu A, Dumitrașcu D, Brisc C, Nedelcu L, Trifan A, Braticevici CF. Nonalcoholic Fatty Liver Disease: Status Quo. Journal of Gastrointestinal and Liver Diseases. 2018; 27(4): 439–448. doi: 10.15403/jgld.2014.1121.274.quo
- Tayyem RF, Al-Dayyat HM, Rayyan YM. Relationship between lifestyle factors and nutritional status and non-alcoholic fatty liverdisease among a group of adult Jordanians. Arabian Journal of Gastroenterology. 2019; 20: 44–49. doi: 10.1016/j.ajg.2019.01.008
- Toshikuni N. Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease. World Journal of Gastroenterology. 2014; 20(26):8393–8406. doi:10.3748/wjg.v20.i26.8393
|
Publication of the article |
«World of Medicine and Biology» №1(79), 2022 year, 094-098 pages, index UDK 616.36+616.36-004 |
DOI |
10.26724/2079-8334-2022-1-79-94-98 |