| About the author: |
O. V. Voloshyna, V. I. Shepitko, L. B. Pelipenko, V. B. Raskaley |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The study of the morphometric parameters of rat hepatocytes during the correction of acute experimental aseptic inflammation of the peritoneum was performed by the injection of cryopreserved placenta. It was found that starting from the 10th day of the experiment, the mean values of hepatocytes’ large and small diameters, as well as the cell area, tended to increase. The value of the nuclear-cytoplasmic index from the 2nd to the 14th day of the experiment was higher than in the intact group. In the study of the size of hepatocytes’ nuclei from the 3rd–5th day of the experiment, a gradual increase in their large and small diameters was noted, which reached maximum values on the 7th and 10th days. Analysis of morphometric parameters proves the efficacy of cryopreserved placenta in the treatment of inflammatory processes. |
| Tags |
experiment, diameters of hepatocytes, morphometric study |
| Bibliography |
- Bahriy MM, Dibrova VA, Popadynets OH, Hryshchuk MI. Metodyky morfolohichnykh doslidzhen. Vinnytsya: Nova knyha; 2016. 328 s. [in Ukrainian]
- Voloshyna OV, Hryhorenko AS, Donets IM. Metody eksperymentalnykh doslidzhen hepatotsytiv pry aseptychnomu perytoniti. Visnyk Ukrayinskoyi medychnoyi stomatolohichnoyi akademiyi. Aktualni problemy suchasnoyi medytsyny. 2018; T. 18; 2(62): 151–154. [in Ukrainian]
- Voloshyna OV, Shepitko VI. Morfolohichna struktura hepatotsytiv pry aseptychnomu zapalenni ocherevyny shchuriv. Svit medytsyny ta biolohiyi. 2018; 4(66):149–151. DOI 10.26724/2079-8334-2018-4-66149-151. [in Ukrainian]
- Holtsev AN, Yurchenko TN. Platsenta: kriokonservirovanie, klinicheskoe primenenie. Kharkov: Brovin AV: 2013. 317 s. [in Russian]
- Horalskyi LP, Khomych VT, Kononskyi OI. Osnovy histolohichnoyi tekhniky i morfofunktsionalni metody doslidzhen u normi ta pry patolohiyi. Zhytomyr: “Polissya”; 2015. 286 s. [in Ukrainian]
- Dhebuadze MA. Morfolohichna reaktsiya pechinky ta selezinky bakterialnoyi intoksykatsiyi pry eksperymentalnomu sepsysi. Svit medytsyny ta biolohiyi. 2015; 2(50):126–8. [in Ukrainian]
- Lapach SN, Chubenko AV, Babich PN. Statisticheskiye metody v mediko-biologicheskikh issledovaniyakh s ispolzovaniyem Excel. Kyiv: Morion; 2000. 320 s. [in Russian]
- Maleyev VV, Sitnikov IG, Bokhonov MS. Voprosy gepatologii. Sankt-Peterburg: Spets. Lit.: 2016. 367 s. [in Russian]
- Razumova MS, Litvinova YES, Kharchenko AV, Dudka VT, Konoplya AI. Morfologicheskiye izmeneniya pecheni pri eksperimentalnoy ostroy toksicheskoy gepatopatii i ikh farmakologicheskaya korrektsiya. Morfologiya. 2017; 151(3):99. [in Russian]
- Rekomendatsii po primeneniyu gidrolizata chelovecheskoy platsenty pri zabolevaniyakh pecheni: Utverzhdeno XVI Syezdom NOGR; Moskva; 2016 Noyab 24–25. Eksperimental. i Klin. Gastroenterologiya. 2016; 136(12):75–7. [in Russian]
- Yunkerov VI, Grigoryev SG, Rezvantsev MV. Matematiko-statisticheskaya obrabotka dannykh meditsinskikh issledovaniy. Sankt-Peterburg: VmedA; 2011. 318 s. [in Russian]
- Lutsenko ED, Ostankov MV, Bondarovich NA, Goltsev AN. Influence of application of cryopreserved placental cell suspension on indices of peripheral blood and bone marrow of animals with adjuvant arthritis. Probl Cryobiol Cryomed 2019; 29(1):028–043. https://doi.org/10.15407/cryo29.01.028
- Prokopiuk VYu, Falko OV, Karpenko VG, Chub OV, Loginova OO. Influence of native and cryopreserved placental derivatives on the splenocyte functional characteristics in vitro. Bulletin of problems biology and medicine. 2018; Issue 2 (144):221–4. DOI: 10.29254/2077-4214-2018-2-144-221-224
- Overi D, Caprino G, Franchitto A. Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis. Cells. 2020 Mar; 9(3): 590. DOI: 10.3390/cells9030590
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| Publication of the article |
«World of Medicine and Biology» №1(79), 2022 year, 174-178 pages, index UDK 616.36-018.1-06:616.381-002.1-021.4:615.368-02:618.46-026.656]-092.9 |
| DOI |
10.26724/2079-8334-2022-1-79-174-178 |
