| About the author: |
S. S. Popko, V. M. Yevtushenko |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
At present, the question of the reaction of the components of the local link of the innate immunity of the respiratory system under conditions of allergic inflammation in most aspects remains open. The study was carried out on male guinea pigs (animals with experimental ovalbumin-induced airways allergic inflammation). Morphological changes were investigated in structural components of the lung. We have found that an increase in the number of PAS-positive goblet cells is accompanied by hypersecretion of mucus and surfactant, functional hyperactivity of type II pneumocytes and alveolar macrophages in the early stages of the development of airways allergic inflammation (p<0.05). Adaptive immune response manifests in the late period of development of allergic inflammation by an increase in the number of lymphoid nodules. Identified changes reflect the manifestations of nonspecific and specific resistance of the lung, represented by protective and compensatory changes in its structural components. Our study suggests that the epithelium of the airways and the respiratory part of the lungs are important modulators of the inflammatory and immune responses of the respiratory system due to the effect of allergens. |
| Tags |
animals, asthma, goblet cells, ovalbumin, PAS reaction surfactant |
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| Publication of the article |
«World of Medicine and Biology» №1(79), 2022 year, 218-222 pages, index UDK 611.24.018:577.112.85]:616.2-018.73-002-021.5-092.9:599.324.7 |
| DOI |
10.26724/2079-8334-2022-1-79-218-222 |
