| About the author: |
V. S. Shkolnikov, L. L. Zalevsky, T. Yu. Shkolnikova |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to establish macro- and morphometric parameters of cerebellum and cytoarchitectonics of its structures. Morphometric, anatomical-histological, and immunohistochemical studies of cerebellum of 116 human embryos and fetuses aged from 6–7 weeks up to 39–40 weeks were performed. There were no congenital anomalies of central nervous system. During intrauterine development, there is a tendency to gradually increase in thickness of cerebellum intermediate layer due to development of neuronal glial complexes. While ventricular layer is gradually thinned by reducing the intensity of neural cell proliferation. The highest intensity of neural cell proliferation in the embryonic period occurred in the ventricular and outer granular layers, and the lowest intensity – in the intermediate layer. In the radial direction, radial glia fibers passed through all cerebellum layers and ended in the outer granular layer. |
| Tags |
intrauterine development, cerebellar hemispheres, cerebellar vermis morphometric parameters, neurons, radial glia |
| Bibliography |
- Bartheld CS, Bahney J, Herculano-Houzel S. The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting. J Comp Neurol. 2016 Dec 15;524(18):3865–3895. doi: 10.1002/cne.24040.
- Cho КН. Early fetal development of the human cerebellum. Surg Radiol Anat. 2011 Aug 33(6):523–530. doi: 10.1007/s00276-011-0796-8.
- Hibi M, Shimizu T. Development of the cerebellum and cerebellar neural circuits. Dev Neurobiol. 2012 Mar 72:282–301. doi:10.1002/dneu.20875.
- Marzban H, Del Bigio MR, Alizadeh J, Ghavami S, Zachariah RM, Rastegar M. Cellular commitment in the developing cerebellum Front. Cell. Neurosci. 2015 Jan 12;8:450. doi: 10.3389/fncel.2014.00450.
- Rahimi-Balaei M, Bergen H, Kong J, and Marzban H. Neuronal Migration During Development of the Cerebellum. Front. Cell. Neurosci. 2018 Dec 12:484. doi: 10.3389/fncel.2018.00484.
- Rakic P. Evolution of the neocortex: a perspective from developmental biology. Nature Reviews Neuroscience. 2009 10:724–735.
- Rybachuk OA, Pivneva TA. The role of neural stem cells in the regeneration of the central nervous system. Physiology. 2013.59 (2): 111–121.
- Sarnat HB, Flores-Sarnat L, Auer RN. Sequence of synaptogenesis in the fetal and neonatal cerebellar system - part 1: Guillain-Mollaret triangle (dentato-rubro-olivo-cerebellar circuit). Dev Neurosci. 2013 June; 35(1):69–81. doi: 10.1159/000350503.
- Shkolnikov VS, Zalevsky LL, Stelmashchuk PO, Tykholaz VO, Zalevskaya IV, inventor; Vinnytsia Pirohov Memorial National Medical University. Method of fixing cerebellum in prenatal period of human ontogenesis for immunohistochemical research. Patent of Ukraine No. 117723. 2018 Sep 10.
- Volpe J. Cerebellum of the premature infant: rapidly developing, vulnerable, clinically important. Child Neurol. 2009 Sep 24(9):1085–1104. doi:10.1177/0883073809338067.
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| Publication of the article |
«World of Medicine and Biology» №1(79), 2022 year, 249-254 pages, index UDK 611.817.1:612.646/.647:572.7 |
| DOI |
10.26724/2079-8334-2022-1-79-249-254 |
