| About the author: |
T. V. Horodova-Andrieieva, V. I. Liakhovskyi, A. V. Sydorenko |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The efficacy of vacuum therapy with instillations of L-arginine was studied in combination with its intravenous infusion. Results were in 89 patients, treated for purulent-necrotic soft tissue diseases. Patients were emergency operated on. The main group 44 patients, got the same therapy and intravenous 100 ml of arginine hydrochloride solution daily. 2 3 courses of vacuum therapy, 3 days each were performed. In the main group, signs of intoxication and body temperature returned to normal by an average of 3.1 days. Normalization of the level of leukocytes was observed in 5.4 days. pH-metry from the wound surface, it was found that significant changes in the average pH of patients in the main group were observed for 7 10 days - the beginning of the regeneration phase. The therapy in the main group in comparison with typical local treatment provided accelerated wound cleansing, reduction of microbial contamination and faster transition of purulent-necrotic phase to regeneration. |
| Tags |
purulent-necrotic diseases, vacuum therapy, instillations, arginine, wound healing |
| Bibliography |
- Besedin AM, Malyuk YuYu, Karpenko LI, Sotnikov SV, Ivanskaya LV, Pundyk GM. Vakuum-instyliatsiyna terapiya u khvorykh z syndromom diabetychnoyi stopy. Klin Khir. 2014;11(3):8‑10. [in Ukrainian]
- Horodova-Andrieieva TV, Liakhovskyi VI, Kyzymenko OO, Sydorenko AV. Novi horyzonty kombinovanoyi terapiyi hniyno nekrotychnykh urazhen miakykh tkanyn. Aktualni problemy suchasnoyi medytsyny: Visnyk Ukrainskoyi medychnoyi stomatolohichnoyi akademiyi. 2020 Dec 30;20(4):20
- Kyzymenko OO, Horodova-Andrieieva TV, Liakhovskyi VI, vynakhidnyky; Ukrainska medychna stomatolohichna akademiia, patentovlasnyk. Sposib mistsevoho kombinovanoho likuvannia hniinykh ran miakykh tkanyn iz znachnymy nekrotychnymy defektamy. Patent Ukainy No 132538. 2019 Liut 25. [in Ukrainian]
- Kyzymenko OO, Krasnov OH, Liakhovskyi VI. Kombinovane mistseve likuvannia hniino-nekrotychnykh urazhen syndromu diabetychnoi stopy. Suchasni medychni tekhnolohii. 2018;1:23-8. [in Ukrainian]
- Razmahnin EV, Shangin VA, Kudryavceva OG, Ohlopkov DYu. Vozmozhnosti vakuum-instilliatsionnoy terapii s ispolzovaniem dimeksida i betadina v lechenii gnoynykh ran. Acta Biomed Sci. 2017;2(6):153‑6. https://doi.org/10.12737/article_5a0a8e0d03dc42.56682733. [in Russian]
- Storozhenko ОV, Lihonenko ОV, Іvashchenko DМ, Zubakha АB, Chorna ІО, Shumeiko ІА. Prohnozuvannya perebihu zahoyennya ran u patsiyentiv, yaki strazhdayut alerhiyeyu na antybiotyky. Klin Khir. 2018;85(5):40-3. https://doi.org/10.26779/2522-1396.2018.05.40. [in Ukrainian]
- Shablovskaya TA, Panchenkov DN. Sovremennye podhody k kompleksnomu lecheniyu gnoyno-nekroticheskikh zabolevaniy mjagkikh tkaney. Bulletin of experimental and clinical surgery. 2013;4(6):498‑518. [in Russian]
- Shkvarkovskyi IV, Antoniuk TV, Filipets OI. Zastosuvannia vakuumnykh metodiv sanatsiyi v likuvanni hniynykh zakhvoriuvan miakykh tkanyn. Buk Med Herald. 2012;vol.16;4(64):184‑7. https://doi.org/10.31718/2077-1096.20.4.20. [in Ukrainian]
- Gambardella J, Khondkar W, Morelli MB, Wang X, Santulli G, Trimarco V. Arginine and endothelial function. Biomedicines. 2020;8(8):277. https://doi.org/10.3390/biomedicines8080277.
- Kim PJ, Attinger CE, Steinberg JS, Evans KK, Lehner B, Willy C, et al. Negative-pressure wound therapy with instillation: international consensus guidelines. Plast Reconstr Surg. 2013 Dec;132(6):1569‑79. doi: 10.1097/PRS.0b013e3182a80586
- Zubakha AB, Lihonenko OV, Chorna IO, Shumejko IA, Storozhenko OV, Skotarenko TA, et al. Combination of ultraviolet radiation of autologous blood, negative pressure wound therapy, and endolymphatic antibacterial therapy in the treatment of post-traumatic wound infections. World of Medicine and Biology. 2021;4(78):60‑5. http://dx.doi.org/10.26724/2079-8334-2021-4-78-60-65.
|
| Publication of the article |
«World of Medicine and Biology» №2(80), 2022 year, 043-047 pages, index UDK 615.811.3+615.032:546.17]:616-002.3-089 |
| DOI |
10.26724/2079-8334-2022-2-80-43-47 |
