| About the author: |
M. K. Ismayilova |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Being one of the relevant areas of modern biology and medicine, the study of the immune system in the implementation of the human reproductive function is important and there is no complete picture reflecting changes in the concentrations of the most known cytokines in blood serum. The study has involved 40 women with infertility and 20 of them with a physiological menstrual cycle examination. The concentration of cytokines in the blood serum of the women has been determined by the immunoenzyme method using commercial BioSOURCE kits. Analysis of the dynamics of changes in IFNγ has revealed that its average level in the group of patients with infertility has been 7.07±1.01 pg/ml, and significantly exceeded the values in the control group by 1.8 times. High concentrations of IFNγ are determined in many complications of the physiological course of pregnancy. It also acts as a mediator of pathological immunoinflammatory processes in various human diseases. It has been found that in women with infertility, the TNF-α level has been 32.82±9.14 pg/ml, which has significantly exceeded the values in the control group by 6.7 times. The significant predominance of proinflammatory cytokines in pregnants’ serum is an unfavorable prognostic sign. And further studies of cytokine production open up prospects for substantiating and increasing the effectiveness of assisted reproductive technologies. |
| Tags |
reproductive function, pregnancy, interleukin-2, tumour necrosis factor-α, interferon-γ |
| Bibliography |
- Besplodnyy brak: versii i kontraversii. Edited by Radzinsky VE. Moscow: GEOTAR-Media; 2018. 404 s. [In Russian]
- Likhachov VK, Shymansʹka YaV, Dobrovolska LM, Akimov OYe, Makarov OH. Zminy aktyvnosti indutsybelnoyi no-syntazy ta arhinazy, yikhniy zvyazok iz rivnem pro- ta protyzapalnykh tsytokiniv v tservikalnomu slyzu u vahitnykh z ekstrakorporalnym zaplidnennyam ta zahrozoyu peredchasnykh polohiv. Aktualni problemy suchasnoyi medytsyny: Visnyk Ukrayinskoyi medychnoyi stomatolohichnoyi akademiyi. 2021; 21, 3 (75) 21–25. DOI: 10.31718/2077-1096.21.3.21 [In Ukrainian]
- Motovilova NO, Kogan IYu, Syssoev KA, Buinova AN, Griaznov AYu, Totolyan AA. Rol nekotorykh tsitokinov v effektivnosti lecheniya besplodiya metodom ekstrakorporalnogo oplodotvoreniya. Medical Immunology (Russia). 2012; 14(4-5):373–382. https://doi.org/10.15789/1563-0625-2012-4-5-373-382. [In Russian]
- Tarasenko KV, Gromova AM. Patohenetichne znachennya prozapalnykh tsitokіnіv u rozvytku uskladnen vahіtnostі u zhіnok z ozhirіnnyam. Pedіatrіya, akusherstvo ta hіnekologіya. 2012 (2 (450): 52–55 [In Ukrainian]
- Alijotas-Reig J, Esteve-Valverde E, Ferrer-Oliveras R, Llurba E, Gris JM. Tumor Necrosis Factor-Alpha and Pregnancy: Focus on Biologics. An Updated and Comprehensive Review. Clin Rev Allergy Immunol. 2017 Aug; 53(1):40–53. doi: 10.1007/s12016-016-8596-x. PMID: 28054230.
- Inha Lee, So Hyun Ahn. Hye In Kim, Hye Won Baek, YunJeongPark, Heeyon Kim, et al. Cytokines in culture media of preimplantation embryos during in vitro fertilization: Impact on embryo quality. Cytokine. 2021; 148, December 2021; 155714. https://doi.org/10.1016/j.cyto.2021.155714
- Lin YH, Chen YH, Chang HY, Au HK, Tzeng CR, Huang YH. Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies. Int J Mol Sci. 2018; 19(8):2385. Published 2018 Aug 13. doi:10.3390/ijms19082385.
- Milcwski R, Milevvska AJ, Czemiecki J, Lcsnicwska M, Wolczynski S. Analysis of the demographic profile of patients treated for infertility using assisted reproductive techniques in 2005-2010. Ginekol Pol. 2013; 84(7): 609–614
- Osakue N, Onyenekwe CC, Ehiaghe FA, Ahaneku JE, Ikechebelu JI, Igberase GO, et al. Maternal Serum Levels of Interferon-gamma, Tumor Necrotic Factor-alpha and Progesterone of Infertile Women on In vitro Fertilization before and after Treatment. Annual Research & Review in Biology. 2020; 35(4), 38–44. https://doi.org/10.9734/arrb/2020/v35i430210
- Rouchou B. Consequences of infertility in developing countries. Perspect Public Health. 2014; 133(3): 174–179
- Trunov A, Obukhova O, Gorbenko O, Shvayk A, Trunova L. Cytokines, estradiol and progesterone in the plasma of women of reproductive age with pelvic inflammatory disease in remission. Advances in Bioscience and Biotechnology. 2013; 4:727–730. doi: 10.4236/abb.2013.46096.
- Van Oostrum N, De Sutter P, Meys J, Verstraelen H. Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta¬-analysis. Hum Reprod. 2013; 28(7): 1809–1815.
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| Publication of the article |
«World of Medicine and Biology» №2(80), 2022 year, 070-073 pages, index UDK 618.177-089.888.11 |
| DOI |
10.26724/2079-8334-2022-2-80-70-73 |
