| About the author: |
V. O. Romanova, N. V. Kuzminova, T. V. Marchak, S. E. Lozinsky, I. I. Knyazkova, O. M. Kulchytska, Yu. L. Shkarivsky |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The data of 135 patients with an uncomplicated course of the disease and 27 with an unfavorable outcome were analyzed for assessment of the prognostic significance of markers of endothelial dysfunction as predictors of an unfavorable prognosis in patients with coronary artery disease. A prospective 2-year study showed that unfavorable cardiovascular events were observed significantly more often in the group of patients with coronary artery disease with an initial elevated level of biomarkers of endothelial dysfunction compared to individuals whose level of these biomarkers was within the reference values. The presence of myocardial infarction at the start of observation, decreased left ventricular ejection fraction <50 % and increased levels of endothelial dysfunction markers: pregnancy-associated plasma protein A, soluble vascular cell-adhesion molecules and, to a lesser extent, endothelin-1 – have a significant predictive value in terms of the probability of adverse cardiovascular events. |
| Tags |
endothelial dysfunction,coronary artery disease,patients’ prognosis,pregnancy-associated plasma protein A,soluble vascular cell-adhesion molecules,endothelin-1 |
| Bibliography |
- Belokopytova IS, Moskalets OV, Paleyev FN, Zotova OV. Diagnosticheskoye znacheniye molekul adgezii sICAM-1 i sVCAM-1 pri ishemicheskoy bolezni serdtsa. Ateroskleroz i dislipidemii. 2013;4(12):62–65 [in Russian]
- Kovalenko VM, Kornatskyy VM, editors. Aktualni problemy zdorovya ta minimizatsiya yikh v umovakh zbroynoho konfliktu v Ukrayini: posibnyk. Kyiv: Derzhavna ustanova “Natsionalnyy naukovyy tsentr “Instytut kardiolohiyi imeni akademika M.D.Strazheska”; 2018 [in Ukrainian]
- Shevchenko OP, Shevchenko AO, Kuntsevich NV, Ginzburg LM, Slesareva YuS, Orlova OV. Assotsiirovannyy s beremennostyu protein plazmy A PAPP-A i urovni markerov vospaleniya u bolnykh ishemicheskoy boleznyu serdtsa. Vestnik RGMU. 2010;1:34–40 [in Russian]
- Byelan OV, Mamontova T, Vesnina L, Borzykh OA, Kaidashev IP. Anti-inflammatory and endothelium protective effect of long-term pioglitazone intake in patients suffering from bronchial asthma concurrent with ischemic heart disease. Wiadomosci Lekarskie. 2017;71(4):712–720.
- Cacko A, Kondracka A, Gawałko M, Główczyńska R, Filipiak KJ, Bartoszewicz Z, et al. Novel biochemical predictors of unfavorable prognosis for stable coronary disease. Medicine. 2018;97(37). DOI: 10.1097/md.0000000000012372
- Crea F, Libby P. Acute coronary syndromes. Circulation. 2017;136(12):1155–66. DOI: 10.1161/CIRCULATIONAHA.117.029870
- Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, et al. Endothelin. Pharmacological Reviews. 2016;68(2):357–418. DOI: https://doi.org/10.1124/pr.115.011833
- Jankowich M, Choudhary G. Endothelin-1 levels and cardiovascular events. Trends in Cardiovascular Medicine. 2020;30(1):1–8. DOI:10.1016/j.tcm.2019.01.007.
- Mu W, Chen Mingyou, Gong Z, Zheng F, Xing Q. Expression of vascular cell adhesion molecule-1 in the aortic tissues of atherosclerotic patients and the associated clinical implications. Experimental and Therapeutic Medicine. 2015;10(2):423–8. DOI: 10.3892/etm.2015.2540
- Nilsson E, Kastrup J, Sajadieh A, Boje Jensen G, Kjøller E, Kolmos H, et al. Pregnancy associated plasma protein-A as a cardiovascular risk marker in patients with stable coronary heart disease during 10 years follow-up – a CLARICOR trial sub-study. Journal of Clinical Medicine. 2020;9(1):265. DOI: 10.3390/jcm9010265
- Romanova V, Sierkova V, Kuzminova N. P885Levels of soluble vascular cell adhesion molecule-1 and pregnancy-associated plasma protein A as the criteria of coronary heart disease destabilization. European Heart Journal. 2017;38(suppl_1). DOI:10.1093/eurheartj/ehx501.p885
- Serkova VK, Pavlov SV, Romanava VA, Monastyrskiy YI, Ziepko SM, Kuzminova NV, et al. Medical expert system for assessment of coronary heart disease destabilization based on the analysis of the level of soluble vascular adhesion molecules. SPIE Proceedings. 2017;10445:104453O–8. DOI:10.1117/12.2280984
- Torres Crigna A, Link B, Samec M, Giordano FA, Kubatka P, Golubnitschaja O. Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine. EPMA Journal. 2021;12(3):265–305. DOI: 10.1007/s13167-021-00248-z
- Townsend N, Kazakiewicz D, Lucy Wright F, Timmis A, Huculeci R, Torbica A, et al. Epidemiology of Cardiovascular Disease in Europe. Nature Reviews Cardiology. 2021;19(2):133–43. DOI: 10.1038/s41569-021-00607-3
- Xu S, Ilyas I, Little PJ, Li H, Kamato D, Zheng X, et al. Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: From mechanism to pharmacotherapies. Pharmacological Reviews. 2021;73(3):924–67. DOI: 10.1124/pharmrev.120.000096
|
| Publication of the article |
«World of Medicine and Biology» №3(81), 2022 year, 148-152 pages, index UDK 616.13-002:616.12-005.4-08 |
| DOI |
10.26724/2079-8334-2022-3-81-148-152 |
