| About the author: |
Kh. I. Safarova |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to identify the features of hemodynamics and structural changes in patients with history of acute rheumatic fever, with and without myxomatous degeneration of the valvular-chordal apparatus. The study included 27 patients aged 15–21 years who had a history of acute rheumatic fever. All patients were divided into 2 groups: group I – patients without myxomatous degeneration; group II – patients with signs of myxomatous degeneration. The comparison group consisted of 14 practically healthy individuals of the appropriate age without a “rheumatic” history and echocardiographic signs of damage to the valvular-chordal apparatus. In patients who had history of acute rheumatic fever, an increase of end-diastolic diameter (by 4.8 %; p<0.05) and end-diastolic volume (by 11.9 %; p<0.05) of the left ventricle, was observed. Patients who had myxomatous degeneration, were characterized by a significant increase in end-systolic diameter (by 16.7 %; p<0.001) and end-systolic volume (by 45.1 %; p<0.001), as well as a decrease in ejection fraction (16.8 %; p<0.001). In patients with rheumatic heart disease, left ventricle myocardial remodeling was observed: in myxomatous degeneration – concentric variant was revealed, without myxomatous degeneration – an eccentric variant. So, in patients with acute rheumatic fever, due to compensatory mechanisms, changes in the geometry of the left ventricle occur, which become maladaptive in the presence of myxomatous degeneration. |
| Tags |
acute rheumatic fever,myxomatous degeneration,concentric and eccentric remodeling |
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| Publication of the article |
«World of Medicine and Biology» №4(82), 2022 year, 166-170 pages, index UDK 616.127-089:616.12-002 |
| DOI |
10.26724/2079-8334-2022-4-82-166-170 |
