| About the author: |
O. I. Tiron, R. S. Vastyanov, V. Yu. Shapovalov, O. I. Yatsyna, M. M. Kurtova |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to study the concentration of pituitary and iodine-containing hormones as well as hormones secreted by the parathyroid gland and the adrenal cortex in the dynamics of skin burns in rats under physiological 0.9 % NaCl solution administration. Blood plasma levels of thyroid-stimulating hormone, triiodothyronine, thyroxin, luteinizing hormone, follicle-stimulating hormone, aldosterone, corticosterone, testosterone and parathyroid hormone were determined 1, 3, 7, 14, 21 and 30 days after thermal skin burns in 138 white Wistar rats. The entire dysfunction of axis of hypothalamic-pituitary-thyroid regulation of a biological organism was established. A simultaneous secretory activity changes were shown in several functional regulatory axis – the pituitary-parathyroid gland, the pituitary-adrenal gland and the pituitary-gonads. Authors showed the primarily inhibition and disorganization of the morphological intraglandular organization in the initial time intervals after a skin burn and some spontaneous compensation after 7–14 days of the post-burn period was confirmed in a change of thyroid gland itself and other important endocrine elements secretory activity. NaCl administration is insufficient for therapeutic purposes and it is necessary to develop the effective pathogenetical scheme of thyroid gland functional state correction in skin burns. |
| Tags |
thyroid gland,burning injury,thyroid-stimulating hormone,triiodothyronine,thyroxin,hormonal dysregulation |
| Bibliography |
- Akmayev IG. Neyro-immunno-endokrinnyye vzaimodeystviya: ikh rol v dizregulyatornoy patologii. Patologicheskaya fiziologiya. 2001; 4 :3–10 [in Russian]
- Vastyanov RS, Stoyanov AN, Demidov VM, Bylskiy DV, Antonenko SA, Neskoromnaya NV, et al. Povrezhdeniya travmaticheskogo i gipoksicheskogo geneza: obshchnost' patogeneticheskikh mekhanizmov. Journal of Education, Health and Sport. 2016; 6 (9) :285–304. doi. http://dx.doi.org/10.5281/zenodo.61768 [in Russian]
- Voyenno-poliova hirurgiia: pidruchnyk. Red. Ja.L. Zarutskyi, V.Ja. Bilyi. Kyiv. FENІKS, 2018: 544 [in Ukrainian]
- Kryzhanovskiy GN. Nekotoryye obshchebiologicheskiye zakonomernosti i bazovyye mekhanizmy razvitiya patologicheskikh protsessov. Arkhiv patologii. 2001; 6 :44–49 [in Russian]
- Nebesna ZM, Yeroshenko HA. Histolohichni ta histokhimichni zminy lehen pry eksperymentalniy termichniy travmi. Svit medytsyny ta biolohiyi. 2015; 2(49) :106–110 [in Ukrainian]
- Chernyakova HM, Minukhin VV, Voronin YeP. Suchasnyy pohlyad na mistseve likuvannya opikiv z infektsiynoyu skladovoyu. Visnyk problem biolohiyi i medytsyny. 2016; 4(133) :68–72 [In Ukrainian]
- Dentice M, Marsili A, Zavacki A-M, Larsen PR, Salvatore D. The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation. Biochem Biophys Acta. 2013; 1830(7) :3937–3945. doi: 10.1016/j.bbagen.2012.05.007.
- Duncan Bassett JH, Williams GR. Role of Thyroid Hormones in Skeletal Development and Bone Maintenance. Endocr Rev. 2016; 37(2): 135–187. doi: 10.1210/er.2015–1106
- Gunas I, Dovgan I, Masur O. Method of thermal burn trauma correction by means of cryoinfluence. Abstracts are presented in zusammen mit der Polish Anatomical Society with the participation of the Association des Anatomistes Verhandlungen der Anatomischen Gesellschaft, Olsztyn. Jena-Munchen Der Urban & Fischer Verlag, 1997 :105.
- Hamblin MR. Novel pharmacotherapy for burn wounds: what are the advancements. Expert Opin Pharmacother. 2019; 20(3) :305–321. doi: 10.1080/14656566.2018.1551880
- Hatch-McChesney A, Lieberman HR. Iodine and Iodine Deficiency: A Comprehensive Review of a Re-Emerging Issue. Nutrients. 2022; 14(17) :3474. doi: 10.3390/nu14173474
- Hughes A, Almeland SK, Leclerc T, Ogura T, Hayashi M, Mills J-A, Norton I, Potokar T. Recommendations for burns care in mass casualty incidents: WHO Emergency Medical Teams Technical Working Group on Burns (WHO TWGB) 2017-2020. Burns. 2021; 47(2) :349–370. doi: 10.1016/j.burns.2020.07.001
- Jeschke MG, Gauglitz GG, Kulp GA, Finnerty CC, Williams FN, Kraft R, Suman OE, et al. Long-Term Persistance of the Pathophysiologic Response to Severe Burn Injury. PLoS One. 2011; 6(7) e21245. doi: 10.1371/journal.pone.0021245
- Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020; 6(1) :11. doi: 10.1038/s41572-020-0145-5
- Tiron OI. Indicators of the cell cycle in the thyroid gland in rats when using infusion of 0.9 % NaCl solution on the background of thermal skin burns // Reports of Morphology. 2019; 25(3) :52–57. doi 10.31393/morphology-journal-2019-25(3)-09
|
| Publication of the article |
«World of Medicine and Biology» №4(82), 2022 year, 246-251 pages, index UDK 616.441:599.323.4-008.64:615.459+616-001.17 |
| DOI |
10.26724/2079-8334-2022-4-82-246-251 |
