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    O. Ya. Shuturma, Z. M. Nebesna, N. V. Ohinska, O. Y. Zarichna, T. A. Lyebyedyeva

    MORPHOMETRIC ANALYSIS OF THE STRUCTURAL COMPONENTS OF THE DUODENAL WALL IN SIMULATED PANCREATITIS


    About the author: O. Ya. Shuturma, Z. M. Nebesna, N. V. Ohinska, O. Y. Zarichna, T. A. Lyebyedyeva
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The paper presents the data of the morphometric study of the duodenal wall in cryogenic pancreatitis. It has been established that the degree of morphometric changes correlated with the duration of the simulated pathological process. An increase in the thickness of the mucous membrane, the height and thickness of the villi, the thickness of the lamina propria of the mucous membrane and the submucous layer has been noted. It was associated with edema and the inflammatory process in the investigated organ. There was also a tendency to increase in the width and depth of crypts, the height of columnar epitheliocytes in the middle part of the villi, which indicated pronounced hypertrophic changes.
    Tags alimentary system,villi,crypt,duodenum,cryogenic pancreatitis,morphometry
    Bibliography
    • Hodlevskyi AI, Savaliuk SI, Balabuieva VV, Satsyk OS. Prohnostychne znachennia otsinky strukturnykh zmin slyzovoi obolonky dvanadtsiatypaloi kyshky u khvorykh na hostryi alimentarnyi pankreatyt starshoi vikovoi hrupy. Ukrainska medychna stomatolohichna akademiia. 2014;13(41):70-4. [in Ukrainian]
    • Horalskyi LP, Khomych VT, Kononskyi OI. Osnovy histolohichnoi tekhniky i morfofunktsionalni metody doslidzhen u normi ta pry patolohii. Zhytomyr: Polissia; 2011. 288 s. [in Ukrainian]
    • Banter Lucas R, Maatman Thomas K, McGuire Sean P, Ceppa Eugene P, House Michael G, et al. Duodenal complications in necrotizing pancreatitis: Challenges of an overlooked complication. The American Journal of Surgery. 2020. S0002961020307455. doi:10.1016/j.amjsurg.2020.11.022
    • Ceranowicz P, Cieszkowski J, Warzecha Z, Dembiński A. Experimental models of acute pancreatitis. Postepy Hig Med Dosw. 2015;21;69:264-9. doi: 10.5604/17322693.1141101.
    • Cherkasov VG, Tymoshenko IO. Structural changes of duodenal mucosa enterocytes of rats in burn skin injury under experiment streptozotocin-induced diabetes mellitus. Reports of Morphology. 2019; 25(1):55-61. doi: 10.31393/morphology-journal-2019-25(1)-08.
    • Cherkasova V. The role of endogenous intoxication in acute experimental pancreatitis. Scientific and practical journal. 2018;2(1):34-37.
    • Cui R, Zhou L, Yan X, Jin Z, Zhang H. Clinicopathological features of duodenal bulb biopsies and their relationship with upper gastrointestinal diseases. Ann Diagn Pathol. 2019 Jun;40:40-44. doi: 10.1016/j.anndiagpath.2019.02.006.
    • Li J, Liu Q, Liu Z, Cen C, Yang Y, Ye J et al. Acute pancreatitis associated with duodenal obstruction induced by groove pancreatitis: A case report. Medicine (Baltimore). 2021;100(22):e26139. doi:10.1097/MD.0000000000026139
    • Mayerle J, Sendler M, Hegyi E, Beyer G, Lerch MM, Sahin-Tóth M. Genetics, Cell Biology, and Pathophysiology of Pancreatitis. Gastroenterology. 2019;156(7):1951-1968.e1. doi: 10.1053/j.gastro.2018.11.081.
    • Puthanmadhom Narayanan S, O'Brien DR, Sharma M, Smyrk TC, Graham RP, Grover M, et al. Duodenal Mucosal Barrier in Functional Dyspepsia. Clin Gastroenterol Hepatol. 2022 May;20(5):1019-1028.e3. doi: 10.1016/j.cgh.2021.09.029.
    • Usenko O, Khomiak I, Khomiak A, Tereshkevich I, Rotar O, Malik A. Duodenum-preserving surgical approach to the treatment of paraduodenal pancreatitis . HPB. 2021;23:s218. doi:10.1016/j.hpb.2020.11.548
    • Volkov КS, Shuturma ОYa, Nebesna ZМ, Getmaniuk ІB, Tupol LD. Histological changes in the duodenal wall in experimental pancreatitis. World of Medicine and Biology. 2018;1(63):100-4
    Publication of the article «World of Medicine and Biology» №4(82), 2022 year, 252-255 pages, index UDK 616.342-91.8:616.37-002]-092.9
    DOI 10.26724/2079-8334-2022-4-82-252-255