| About the author: |
S. S. Adamiv, A. E. Dienga, T. H. Verbytska, S. A. Shnaider, V. Ya. Skyba, O. L. Kordonets, A. Jenča |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The study is devoted to determining the effect of allelic variants of pro-inflammatory IL1B, IL17, TNF and anti-inflammatory IL10 cytokine genes on the severity of gingivitis in children undergoing orthodontic treatment. The study involved 18 children undergoing orthodontic treatment with varying degrees of severity of gingivitis. Dental examination was carried out in a dental office. The data presented in the paper on the effect of genetic polymorphisms of cytokine genes on the severity of gingivitis in children undergoing orthodontic treatment allows timely identification of potential genetic risk groups for inflammatory periodontal diseases for prevention and therapy, taking into account the individual characteristics of the patient. |
| Tags |
gingivitis,oral health,genetic polymorphism,children,polymerase chain reaction |
| Bibliography |
- Kaskova LF, Popyk KM, Ulasevych LP. Fizychni pokaznyky rotovoyi ridyny u ditey shkilnoho viku z riznym stomatolohichnym statusom. World of Medicine and Biology. 2019;4(70):091–094. DOI: 10.26724/2079-8334-2019-4-70-91-94 [in Ukranian]
- Lang TA, Sesik M. Kak opisyvat statistiku v meditsine. Moskva: Prakticheskaya meditsina. 2016; 480. [in Russian]
- Balachandran P, Janakiram C. Prevalence of malocclusion among 8-15 years old children, India - A systematic review and meta-analysis. J Oral Biol Craniofac Res. 2021;11(2):192–199. DOI: 10.1016/j.jobcr.2021.01.011.
- Gurav AN. The association of periodontitis and metabolic syndrome. Dent Res J (Isfahan). 2014;11(1):1–10.
- Ling Y, Puel A. IL-17 and infections. Actas Dermosifiliogr. 2014;105(1):34–40. DOI: 10.1016/S0001-7310(14)70016-X.
- Moudi B, Heidari Z, Mahmoudzadeh-Sagheb H, Moudi M. Analysis of interleukin-10 gene polymorphisms in patients with chronic periodontitis and healthy controls. Dent Res J (Isfahan). 2018;15(1):71–79. DOI: 10.4103/1735-3327.223614.
- Ramamurthy J, Gopalasamy K. Prevalence of Gingivitis In Patients Undergoing Orthodontic Treatment Of Ages 18-25 Years- A Retrospective Study. International Journal of Dentistry and Oral Science. 2020;7(12):1231–1235. DOI: 10.19070/2377-8075-20000243.
- Ruder B, Atreya R, Becker C. Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases. Int J Mol Sci. 2019;20(8):1887. DOI: 10.3390/ijms20081887.
- Schulz S, Porsch M, Grosse I, Hoffmann K, Schaller HG, Reichert S. Comparison of the oral microbiome of patients with generalized aggressive periodontitis and periodontitis-free subjects. Arch Oral Biol. 2019:169–176. DOI: 10.1016/j.archoralbio.2019.01.015.
- Walsh PS, Metzger DA, Higushi R. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques. 2013;54(3):134–9. DOI: 10.2144/000114018.
|
| Publication of the article |
«World of Medicine and Biology» №1(83), 2023 year, 011-014 pages, index UDK [616.311.2-002+616-053.5]:575.117.2 |
| DOI |
10.26724/2079-8334-2023-1-83-11-14 |
