| About the author: |
O. V. Dienha, V. B. Pyndus, K. V. Litovkin, S. A. Shnaider, P. Džupa, V. M. Pochtar, O. V. Suslova |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The study is devoted to finding the association of single-nucleotide polymorphisms rs1799946–52G>A of the DEFB1 gene, rs2274756–8202 A>G of the MMP9 gene and rs689466–1195 A>G of the COX2 gene with periodontitis in the Ukrainian population. 34 patients participated in the research. They were divided into 2 groups (the study group, which included 22 patients with periodontitis of various degrees of severity; the control group, which included 12 healthy individuals). The dental examination was carried out in a dental office. As a result of the research, it was established that the rs689466 was associated with periodontitis risk under the allelic model and dominant model. Rs1799946 and rs2274756 did not show any association with the disease in the Ukrainian population. |
| Tags |
periodontitis,oral health,genotyping,human beta-defensin-1,matrix metalloproteinase-9,cyclooxygenase-2 |
| Bibliography |
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| Publication of the article |
«World of Medicine and Biology» №1(83), 2023 year, 053-056 pages, index UDK [616-053.8+616.31-002]:575.117.2 |
| DOI |
10.26724/2079-8334-2023-1-83-53-56 |
