| About the author: |
Y. O. Yemchenko, I. P. Kaydashev, K. Ye. Ishcheykin, O. V. Bezeha |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
In patients with moderate psoriasis with concomitant metabolic syndrome, the indicators of general clinical and biochemical blood tests and carbohydrate and lipid metabolism were determined, and indicators of systemic inflammation were assessed by the level of susceptible C-reactive protein, ceruloplasmin, interleukin-6 and tumor necrosis factor-α. A laboratory study found that in patients with moderate psoriasis with concomitant metabolic syndrome, an important role is played by the systemic inflammatory process, which is accompanied by the development of insulin resistance, impaired lipid and nitrogen metabolism, and regulation of vascular tone. Furthermore, an increase in the intensity of systemic inflammation is accompanied by an increase in skin lesions, an increase in systolic blood pressure, and a violation of lipid and carbohydrate metabolism. |
| Tags |
psoriasis,metabolic syndrome,systemic inflammation,dyslipidemia,insulin resistance |
| Bibliography |
- Babak OYa, Yarmish NV, Shkolnik VV. Ozhirіnnya yak puskoviy mehanіzm adipocitokіnovoho kaskadu. Medicina transportu Ukrainy. 2022; 2: 94–99. [in Ukrainian].
- Yemchenko YO, Ischeykin KE, Kaidashev IP. Analiz zahvoryuvanosti ta poshirenosti na psoriaz. Aktualni problemy suchasnoyi medytsyny: Visnyk Ukrayinskoyi medychnoyi stomatolohichnoyi akademiyi. 2014; 3(47): 72–78. [in Ukrainian]
- Yemchenko YO, Ischeykin KE, Kaidashev IP. Aspekty formuvannia personifikovanoho pidkhodu do likuvannia komorbidnosti psoriatychnoi khvoroby. 2019; 2 (151):34–38. DOI 10.29254/2077-4214-2019-2-2-151-34-38. [in Ukrainian]
- Kamylov FKh, Mufazalova NA, Kapuler OM. Tsytokinovyi dysbalans v immunopatogeneze psoriaza. Fundamentalni doslidzhennia. 2015; 1 (5):1065–1071. [in Russian]
- Atkinson RL. Could viruses contribute to the worldwide epidemic of obesity Int J Pediat Obes. 2018; 3: Suppl 1: 37–43. doi: 10.1080/17477160801896754.
- Bertheloot D, Latz E. HMGB1, IL-1a, IL-33 and S100 proteins: dualfunction alarmins. Cell Mol Immunol. 2017; 14(1):43–64. doi: 10.1038/cmi.2016.34.
- Brikos C, O´Neill LA. Signaling of toll-like receptors. Handb Exp Pharmacol. 2018; 183: 21–50. doi: 10.1007/978-3-540-72167-3_2.
- Clark RA. Resident memory T cells in human health and disease. Sci Transl Med. 2015; 7 (269):269–274. doi: 10.1126/scitranslmed.3010641.
- Henseler T, Schmitt-Rau K. A comparison between BSA, PASI, PLASI and SAPASI as measures of disease severity and improvement by therapy in patients with psoriasis. Int J Dermatol. 2018 Oct;47(10):1019–23. doi: 10.1111/j.1365-4632.2008.03753.x. PMID: 18986347.
- Harden JL, Krueger JG, Bowcock AM. The immunogenetics of Psoriasis: A comprehensive review. J Autoimmun. 2015 Nov; 64:66–73. doi: 10.1016/j.jaut.2015.07.008.
- Mitsui A, Tada Y, Takahashi T, Shibata S, Kamata M. Serum IL 33 levels are increased in patients with psoriasis. Experimental dermatology. 2015; 3(2):234–239.
- National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI). The practical guide: identification, evaluation, and treatment of overweight and obesity in adults. Bethesda: National Institutes of Health. 2020, NIH publication 00- 4084.
- Suganami T, Tanimoto-Koyama K, Nishida J. Role of the Tolllike receptor 4/NF-kappaB pathway in saturated fatty acidinduced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol. 2017; 27: 84–91. doi: 10.1161/01.ATV.0000251608.09329.9a.
- Zhdan VN, Tkachenko MV, Kitura YeM, Babanina MYu, Kyrian OA. Osteoarthritis and metabolic syndrome: unity of pathogenetic mechanisms. World of Medicine and Biology. 2021. № 4 (78). p. 56–60. DOI: 10.26724/2079-8334-2021-4-78-56-60.
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| Publication of the article |
«World of Medicine and Biology» №1(83), 2023 year, 061-067 pages, index UDK 616.517:612.015.3-002-071 |
| DOI |
10.26724/2079-8334-2023-1-83-61-67 |
