| About the author: |
V. V. Kachkovska, L. N. Prystupa, V. F. Orlovskyi |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The frequency of Arg16Gly polymorphism in the β2-adrenoceptor gene was studied in 553 patients with bronchial asthma depending on the age of onset: in 282 patients with late onset of asthma and 271 patients with early onset. Also, the study included 95 healthy individuals. In the late-onset asthma group Arg/Arg genotype was present in 35.8 %, Arg/Gly genotype – in 52.5 %, Gly/Gly genotype – in 11.7 % of patients, while in the early-onset asthma group, it was present in 26.6; 38.7 and 34.7 % of patients, respectively (χ2=41.26; р=0.001). We observed an increased risk of developing early-onset asthma: it was 2.83 times higher (p=0.001) in the recessive model and 1.87 times higher (p=0.001) in the additive model vs. the major allele homozygotes. No association was found with the risk of late-onset asthma. Gly allele carriers, both heterozygotes, and the minor allele homozygotes have an increased risk of developing early-onset bronchial asthma rather than late-onset asthma. |
| Tags |
bronchial asthma,onset,Arg16Gly polymorphism in the β2 -adrenoceptor gene |
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| Publication of the article |
«World of Medicine and Biology» №1(83), 2023 year, 087-090 pages, index UDK 616.248-052:577.113.1 |
| DOI |
10.26724/2079-8334-2023-1-83-87-90 |
