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    I. O. Komarevtseva, S. N. Smirnov, A. Yu. Ihnatova, I. V. Rudenko, K. V. Balabanova, I. A. Vyshnitska, V. N. Komarevtsev

    ALFA-1-ANTITRYPSIN PREDICTS SEVERE COVID-19, GASTRIC AND RENAL CANCER IN CONDITIONS OF HYPERGLYCEMIA


    About the author: I. O. Komarevtseva, S. N. Smirnov, A. Yu. Ihnatova, I. V. Rudenko, K. V. Balabanova, I. A. Vyshnitska, V. N. Komarevtsev
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation Hyperglycemia with or without blood glucose in diabetes range is an emerging finding not uncommonly encountered in patients with COVID-19. This work is to investigate the association between serum alpha-1-antitrypsin, hyperglycemia, and clinical outcomes in COVID-19, and community-acquired pneumonia, gastric cancer and renal cell carcinoma. Alpha-1-antitrypsin levels in serum was determined by the immunoturbidimetric method. We have set the level of alpha-1-antitrypsin in patients with community-acquired pneumonia and COVID-19 with or without hyperglycemia. Levels of alpha-1-antitrypsin in COVID-19 patients with hyperglycemia who survived > those who did not survive. Concentration of alpha-1-antitrypsin levels in COVID-19 men-patients with hyperglycemia who survived was significantly higher than compared with COVID-19 women-patients with hyperglycemia who survived. The obtained data convincingly demonstrate the value of testing the level of alpha-1-antitrypsin in the blood as one of the important indicators of the effectiveness of cancer diagnosis and prognosis.
    Tags alpha-1-antitrypsin,COVID-19,community-acquired pneumonia,gastric cancer,renal cell carcinoma,hyperglycemia
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    Publication of the article «World of Medicine and Biology» №1(83), 2023 year, 100-105 pages, index UDK 616.61-006:616.65+576.367
    DOI 10.26724/2079-8334-2023-1-83-100-105