| About the author: |
F. A. Tagieva |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Analysis of scientific publications shows that the most important role in the development of insulin resistance accompanying metabolic syndrome is played by adipose tissue hormones-adiponectin, leptin and resistin. The article presents the results of a study conducted to study the role of adiponectin, leptin and resistin in the development of insulin resistance in pregnant women with abdominal obesity and type 2 diabetes mellitus. The results of the study demonstrate the relationship of metabolic and hormonal changes in the examined patients against the background of carbohydrate metabolism disorders. It has been shown that pregnant women with abdominal obesity and type 2 diabetes mellitus have insulin resistance and hyperinsulinemia. In these patients, there was a decrease in the level of adiponectin and an increase in leptin, and there were no differences in the level of resistin in the blood serum. Against the background of insulin resistance, the insulin level and the HOMA-IR index had a negative relationship with the level of adiponectin and resistin and a positive relationship with the level of leptin. The revealed correlations with insulin and the HOMA-IR index allow us to regard a decrease in adiponectin secretion and an increase in leptin production as a component involved in the formation of insulin resistance and metabolic syndrome in pregnant women with abdominal obesity and type 2 diabetes mellitus. |
| Tags |
pregnant women,insulin resistance,adiponectin,leptin,resistin |
| Bibliography |
- Verbovoy AF, Lomonova TV. Adiponektin, rezistin i gormonalno-metabolicheskiye pokazateli u muzhchin s gipotireozom i sakharnym diabetom 2 tipa. Meditsina v Kuzbasse. 2018; 17 (4): 51–56 [in Russian]
- Kovaleva YuV. Gormony zhirovoy tkani i ikh rol v formirovaniyi gormonalngo statusa i patogeneze metabolicheskikh narusheniy u zhenchin. Arterialnaya gipertenziya. 2015; 21 (4): 356–370 [in Russian]
- Petununa NA, Kuzina IA. Rol gormonov zhirovoy tkani v razvitiyi oslozhneniy beremennosti u zhenchin s ozhireniyem. Ozhireniye i metabolism. 2013; 1: 3–8 [in Russian]
- Titov VH. Leptin i adiponektin v patogeneze metabolicheskogo sindroma. Klinicheskaya meditsina. 2014; 4: 20–29 [in Russian]
- Chabanova NB, Matayev SI, Troshina IA. Metabolicheskiye narusheniya pri adipotsitokinovom disbalanse i gestatsionniye oslozhneniya. Ozhireniye i metabolism. 2017; 1: 9–16 [in Russian]
- Blüher M., Mantzoros C.S. From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism. 2015; 64(1):131–145.
- Bo S, Gambino R, Pagani A. Guidi S, Gentile L, Cassader M, Paganoat G F . Relationships between human serum resistin. inflammatory markers and insulin resistance. International Journal of Obesity.2005; 29:1315–1320.
- Farvid M, Ng T, Chan D. Barrett P H R, Watts G F. Association of adiponectin and resistin with adipose tissue compartments, insulin resistance and dyslipidaemia. Diabetes, Obesity and Metabolism. 2005; 7(4):406–413.
- Janke J, Engeli S, Gorzelniak K. Luft FC, Sharma AM. Resistin gene expression in human adipocytes is not related to insulin resistance. Obesity Research.2002; 10:1–5.
- Kaushik K, Satwika S. Variations of adipokines and insulin resistance in primary hypothyroidism. J ClinDiagn Res. 2017; 11(8): 7–9
- Rak A, Mellouk N, Froment P. Dupont J. Adiponectin and resistin: Potential metabolic signals affecting hypothalamopituitary gonadal axis in females and males of different species. Reproduction. 2017;153(6): 215–226.
- Stern JH, Rutkowski JM, Scherer PE. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. CellMetab. 2016;23(5):770–784.
- Tarianyk KА, Kaidashev IP, Shlykova OA, Izmailova OV. The analysis of the change in ghrelin level in patients with different forms of Parkinson’s disease. World of medicine and biology. 2020; 4 (74): 145–149.
- Yemchenko YaA, Ishcheikin KYe, Kaidashev IP. Dynamics of clinical and laboratory indicators in the treatment of patients with psoriasis and concomitant alimentary obesity. World of medicine and biology. 2021; 1 (75):55–58.
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| Publication of the article |
«World of Medicine and Biology» №1(83), 2023 year, 165-168 pages, index UDK 616.36-002:616.379-008:612.018 |
| DOI |
10.26724/2079-8334-2023-1-83-165-168 |
