| About the author: |
N. V. Boruta, V. I. Shepitko, Y. V. Stetsuk, D. S. Dubinin, O. A. Levchenko, A. V. Sydorenko, V. V. Mykhaylenko |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Throughout a person's life, the pancreas, which is the second largest gland (after the liver), is significantly affected by various adverse factors. It is a unique organ that combines external and internal secretory activity, playing an important role in the carbohydrate metabolism of the human body. Today, diseases of the pancreas are one of the most important problems in medicine. Established dystrophic changes of the gland, which were expressed by the formation of fibrous fields, the thickness of the capsule and interlobular connective tissue between the lobes visually increased, a decrease in the area of acini and exocrinocytes was observed, acini lost clear contours and shape due to swelling of the connective tissue. Exocrinocytes of acini lost apical eosinophilia and basal basophilia of the cytoplasm, there was a decrease in the area of the nuclei, which were changed in shape and location. The introduction of triptorelin causes destructive-degenerative changes in the exocrine apparatus of the pancreas, which are characterized by compensatory mechanisms in the early periods of observation, and in the later periods – dystrophic changes in the structural components of the gland are determined, which corresponds to the stage of partial decompensation, a decrease in the activity and functionality of the cellular component of the exocrine apparatus of the pancreas. |
| Tags |
testosterone deprivation,pancreas,acini,exocrinocytes |
| Bibliography |
- Varenyuk IM, Dzerzhynskyy ME. Metody tsyto-gistologichnoyi diagnostyky: navchalnyy posibnyk.– Kyiv: Interservis.2019:256 s. [in Ukranian]
- Zykova NP, Nebesna ZM, Hetmaniuk IB. Mikroskopichni zminy ekzokrynnoi chastyny pidshlunkovoi zalozy v pizni terminy pislia eksperymentalnoi termichnoi travmy shkiry. Visnyk medychnykh i biolohichnykh doslidzhen.2021;2:8:22–5. doi: https://doi.org/10.11603/bmbr.2706-6290.2021.2.12336 [in Ukranian]
- Zabudskaia LR. Normalnaia MRT anatomyia podzheludochnoi zhelezы. Luchevaia dyahnostyka. Luchevaia terapyia. 2017;3:36–1. [in Ukranian]
- Lapach SN, Chubenko AV, Babich PN. Statisticheskiye metody v mediko-biologicheskikh issledovaniyakh s ispolzovaniyem Exсel. Kiev: Morionю 2000. 320 s. [in Ukranian]
- Mokra AP, Shulhai AH, Peleshok OI. Vikovi osoblyvosti morfometrychnykh zmin ekzokrynnoho aparatu pidshlunkovoi zalozy. Visnyk naukovykh doslidzhen. 2015;3:85–9. [in Ukranian]
- Boruta NV. Morphofunctional characteristics of hemomicrocirculatory bed’s vessels of the pancreas in rats and at central deprivation of testosterone synthesis. World of Medicine and Biology.2020;4:164–67. doi: 10.26724/2079-8334-2020-4-74-164-167.
- Desai K, McManus JM, Sharifi N. Hormonal Therapy for Prostate Cancer. Endocr Rev. 2021 May 25;42(3):354–373. doi: 10.1210/endrev/bnab002.
- European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Strasbourg:Council of Europe;1986. 53 p.
- Fungbun N, Tungmahasuk D, Terashima R, Kurusu S, Kawaminami M. Annexin. Annexin A1 is a novel target gene of gonadotropin-releasing hormone in LβT2 gonadotrope cells. J Vet Med Sci. 2018 Jan 27;80(1):116–124. doi: 10.1292/jvms.17-0569.
- Maslova GS, Gopko OF, Skrypnyk IM. The role of arginine/citrulline cycle disorders in the pathogenesis of doxorubicin-induced liver injury associated with nonalcoholic steatohepatitis in rats. World of Medicine and Biology. 2020;2 (72): 188–192. doi: 10.26724/2079-8334-2020-2-72-188-192.
- Robert C, Lebbé C, Lesimple T, Lundström E, Nicolas V, Gavillet B et al. I study of Androgen deprivation therapy in combination with anti-PD-1 in patients pre- treated with anti-PD-1. Clin Cancer Res. 2022 Dec 14;CCR-22-2812. doi: 10.1158/1078-0432.CCR-22-2812.
- Stetsuk YeV, Kostenko VO, Shepitko VI, Goltsev AN. Influence of the 30-days central deprivation of testosterone synthesis on the morphological and functional features of rat testicular interstitial endocrinocytes and sustentocytes. World of Medicine and Biology. 2019;4(70):22833. doi: 10.26724/2079-8334- 2019-4-70-228-233.
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| Publication of the article |
«World of Medicine and Biology» №1(83), 2023 year, 193-196 pages, index UDK 616.37:612.018/.08 |
| DOI |
10.26724/2079-8334-2023-1-83-193-196 |
