English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    A. S. Herashchenko, S. V. Fedorov, M. V. Bielinskyi, N. M. Seredyuk, I. V. Kozlova

    PREDICTING HEART FAILURE IN PATIENTS WITH DIABETES MELLITUS: GALECTIN-3, SST2, AND CAROTID THICKNESS


    About the author: A. S. Herashchenko, S. V. Fedorov, M. V. Bielinskyi, N. M. Seredyuk, I. V. Kozlova
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation Heart failure and Type 2 Diabetes Mellitus are two of the most common chronic conditions affecting adults worldwide. Soluble suppression of tumorigenicity 2 and galectin-3 are two biomarkers that have been studied extensively in recent years as predictors of risk of heart failure in patients with Type 2 Diabetes Mellitus. Carotid Intima Media Thickness is a well-established measure of arterial stiffness and vascular aging. We enrolled 154 patients with diabetes mellitus who presented to a private medical clinic: 83 patients in the diabetes mellitus with heart failure group and 71 patients in the diabetes mellitus–only group. We found that the diabetes mellitus with heart failure group had a significantly higher body mass index, mean Carotid Intima Media Thickness, and Galectin-3 compared to the diabetes mellitus group. However, there was no significant difference in age, gender composition, left ventricular ejection fraction, HbA1c, and soluble suppression of tumorigenicity 2 levels between the two groups.
    Tags heart failure,diabetes mellitus,galеctin-3,low-grad inflammation,carotid intima media thickness
    Bibliography
    • Katerenchuk IP. Klinichna otsinka, diahnostychne i prohnostychne znachennia deiakykh suchasnykh laboratornykh doslidzhen u patsiyentiv z ishemichnoyu khvoroboyu sertsia. Kardiologiya: vid nauky do praktyky. 2019;(3 (37)):70–81. doi: 10.30702/card:sp.2019.08.037/0307081 [in Ukrainian]
    • Abeysuriya V, Perera BPR, Wickremasinghe AR. Regional and demographic variations of Carotid artery Intima and Media Thickness (CIMT): A Systematic review and meta-analysis. PLoS One. 2022;17(7). doi: 10.1371/journal.pone.0268716
    • Appiah D, Capistrant BD. Cardiovascular Disease Risk Assessment in the United States and Low- and Middle-Income Countries Using Predicted Heart/Vascular Age. Scientific Reports. 2017;7(1):1–10. doi: 10.1038/s41598-017-16901-5
    • Castiglione V, Chiriaco’ M, Aimo A, Januzzi J, Richards AM, Lam CSP, et al. Prognostic value of sST2 in heart failure patients with diabetes. Eur Heart J. 2021;42(Supplement_1). doi: 10.1093/eurheartj/ehab724.0869
    • Demaison L. Oxidative Stress and Obesity- and Type 2 Diabetes-Induced Heart Failure. Antioxidants (Basel). 2020;9(8):1–3. doi: 10.3390/antiox9080653
    • Jamthikar A, Gupta D, Cuadrado-Godia E, Puvvula A, Khanna NN, Saba L, et al. Ultrasound-based stroke/cardiovascular risk stratification using Framingham Risk Score and ASCVD Risk Score based on “Integrated Vascular Age” instead of “Chronological Age”: a multi-ethnic study of Asian Indian, Caucasian, and Japanese cohorts. Cardiovasc Diagn Ther. 2020;10(4):939. doi: 10.21037/cdt.2020.01.16
    • Jun JE, Kang H, Hwang YC, Ahn KJ, Chung HY, Jeong IK. The association between lipoprotein (a) and carotid atherosclerosis in patients with type 2 diabetes without pre-existing cardiovascular disease: A cross-sectional study. Diabetes Res Clin Pract. 2021; 171:108622. doi: 10.1016/j.diabres.2020.108622
    • Kumar P, Sharma R, Misra S, Kumar A, Nath M, Nair P, et al. CIMT as a risk factor for stroke subtype: A systematic review. Eur J Clin Invest. 2020;50(11): e13348. doi: 10.1111/eci.13348
    • Lakshmi Prabha P, Jayanthy AK, Prem Kumar C, Ramraj B. Prediction of cardiovascular risk by measuring carotid intima media thickness from an ultrasound image for type II diabetic mellitus subjects using machine learning and transfer learning techniques. Journal of Supercomputing. 2021;77(9):10289–306. doi: 10.1007/s11227-021-03676-w
    • Perez HA, Garcia NH, Spence JD, Armando LJ. Adding carotid total plaque area to the Framingham risk score improves cardiovascular risk classification. Archives of Medical Science. 2016;12(3):513–20. doi: 10.5114/aoms.2016.59924
    • Potyazhenko MM, Lyulka NO, Ostapchuk YA. Heart remodeling, treatment of myocardial infarction with diabetes mellitus 2nd type and heart failure. Wiadomości Lekarskie. 2020;73(6):1284–9. doi: 10.36740/WLek202006140
    • Roglic G. WHO Global report on diabetes: A summary. Int J Noncommun Dis. 2016;1(1):3. doi: 10.4103/2468-8827.184853
    • Simeone P, Tripaldi R, Michelsen A, Ueland T, Liani R, Ciotti S, et al. Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss. Cardiovasc Diabetol. 2022;21(1):1–12. doi: 10.1186/s12933-022-01469-w
    • Urbich M, Globe G, Pantiri K, Heisen M, Bennison C, Wirtz HS, et al. A Systematic Review of Medical Costs Associated with Heart Failure in the USA (2014–2020). PharmacoEconomics. 2020;38(11):1219–36. doi: 10.1007/s40273-020-00952-0
    • Vetrone LM, Zaccardi F, Webb DR, Seidu S, Gholap NN, Pitocco D, et al. Cardiovascular and mortality events in type 2 diabetes cardiovascular outcomes trials: a systematic review with trend analysis. Acta Diabetol. 2019;56(3):331–9. doi: 10.1007/s00592-018-1253-5
    Publication of the article «World of Medicine and Biology» №2(84), 2023 year, 045-049 pages, index UDK 616.12-008.46-085:616.379-008.64
    DOI 10.26724/2079-8334-2023-2-84-45-49