About the author: |
M. Yu. Delva, K. S. Skoryk, I. I. Delva |
Heading |
CLINICAL MEDICINE |
Type of article |
Scentific article |
Annotation |
The occurrence and evolution of neuropathic dysesthetic pain in patients with multiple sclerosis during a 2-year observation period was studied. 241 patients were included in the study. Dysesthetic pain was diagnosed using the PainDETECT questionnaire. Patients with newly detected (recurrent) dysesthetic pain were examined at the beginning of the study, after 1, 3 and 6 months depending on the duration of the pain. Over a 2-year period, the cumulative risk of dysesthetic pain was 15.6 % (11.4 %–21.0 %), and the cumulative risk of recurrence was 8.8 % (3.0 %–23.0 %). The first detected (recurrent) dysesthesia lasted more than 3 months in two-thirds of cases. The first detected (recurrent) dysesthesia was mainly localized in the lower back and lower limbs. Patients described dysesthesia both at the time of its occurrence and later, indicating more than 2 descriptors (most often “burning”, “freezing” and “tingling”). The chronicity of dysesthetic pain was associated with the expansion of pain areas, with the transformation of the pain pattern (from pain attacks to constant pain), with a decrease in pain intensity. |
Tags |
multiple sclerosis,neuropathic dysesthetic pain,occurrence,clinical evolution |
Bibliography |
- Delva Mlu, Skoryk KS. Chastota ta klinichni kharakterystyky neiropatychnoho boliu u patsiientiv z rossianym sklerozom Visnyk problem biolohii ta medytsyny. 2022; 1(2);149–150. doi:10.29254/2077-4214-2022-2-1-164-145-157. [in Ukrainian]
- Aborode AT, Pustake M, Awuah WA, Alwerdani M, Shah P, Yarlagadda R et al. Targeting oxidative stress mechanisms to treat Alzheimer’s and Parkinson’s disease: a critical review. Oxidative Medicine and Cellular Longevity. 2022 Jul 31;2022. https://doi.org/10.1155/2022/7934442.
- Feketová S, Waczulíková I, Valkovic P, Mares J. Central pain in patients with multiple sclerosis. Journal of Multiple Sclerosis. 2017;4(3):1–6. DOI: 10.4172/2376-0389.1000208.
- Fiest KM, Fisk JD, Patten SB, Tremlett H, Wolfson C, Warren S et al. Comorbidity is associated with pain-related activity limitations in multiple sclerosis. Multiple sclerosis and related disorders. 2015 Sep 1;4(5):470–6. http://dx.doi.org/10.1016/j.msard.2015.07.014.
- Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S et al. Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Pain®. 2013 May 1;154(5):632–42. https://doi.org/10.1016/j.pain.2012.12.002.
- Heitmann H, Haller B, Tiemann L, Mühlau M, Berthele A, Tölle TR, et al. Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study. Pain. 2020 Apr 1;161(4):787–96.doi: 10.1097/j.pain.0000000000001767.
- Khan F, Amatya B, Kesselring J. Longitudinal 7-year follow-up of chronic pain in persons with multiple sclerosis in the community. Journal of neurology. 2013 Aug;260(8):2005–15. https://doi.org/10.1007/s00415-013-6925-z.
- Khan N, Smith MT. Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology. 2014 Feb;22(1):1–22. DOI 10.1007/s10787-013-0195-3.
- Kister I, Bacon TE, Chamot E, Salter AR, Cutter GR, Kalina JT, Herbert J. Natural history of multiple sclerosis symptoms. International journal of MS care. 2013;15(3):146–56. https://doi.org/10.7224/1537-2073.2012-053.
- Moisset X, Ouchchane L, Guy N, Bayle DJ, Dallel R, Clavelou P. Migraine headaches and pain with neuropathic characteristics: comorbid conditions in patients with multiple sclerosis. PAIN®. 2013 Dec 1;154(12):2691–9. https://doi.org/10.1016/j.pain.2013.07.050.
- Spirin NN, Kiselev DV, Karpova MS. Neuropathic Pain in Multiple Sclerosis Patients. Neuroscience and Behavioral Physiology. 2022 May;52(4):477–85. doi 10.1007/s11055-022-01264-w.
- Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA. A classification of chronic pain for ICD-11. Pain. 2015 Jun;156(6):1003. doi: 10.1097/j.pain.0000000000000160.
- Truini A, Barbanti P, Pozzilli C, Cruccu G. A mechanism-based classification of pain in multiple sclerosis. Journal of neurology. 2013 Feb;260(2):351–67. doi: 10.1007/s00415-012-6579-2.
- Valentine TR, Alschuler KN, Ehde DM, Kratz AL. Prevalence, co-occurrence, and trajectories of pain, fatigue, depression, and anxiety in the year following multiple sclerosis diagnosis. Multiple Sclerosis Journal. 2022 Apr;28(4):620–31. https://doi.org/10.1177/13524585211023352.
- Young J, Amatya B, Galea MP, Khan F. Chronic pain in multiple sclerosis: A10-year longitudinal study. Scandinavian journal of pain. 2017 Jul 1;16(1):198–203. https://doi.org/10.1016/j.sjpain.2017.04.070.
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Publication of the article |
«World of Medicine and Biology» №3(85), 2023 year, 056-060 pages, index UDK 616.832-004.2-071 |
DOI |
10.26724/2079-8334-2023-3-85-56-60 |