| About the author: |
I. M. Shukhtina, V. V. Shukhtin, O. V. Bachynska |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The state of the liver was determined based on indices of liver enzyme activity and ultrasound diagnostics in patients with gastric and duodenal ulcers against the background of chronic helicobacteriosis. 127 patients (74 men and 53 women) with peptic ulcer disease of the stomach and duodenum were examined, in all cases Helicobacter Pylori was verified as an etiological factor. The diagnosis was confirmed endoscopically with further analysis of the biopsy material. Urease and microbiological tests were positive in all patients, transabdominal ultrasound was additionally performed. A probably higher degree of insemination of Helicobacter Pylori was found on the mucous membrane of the body of the stomach according to the small curvature (p<0.05) in relation to the topographic zones of the antral area. In most patients, accompanying changes in the gallbladder, pancreas, and liver were observed. The own results of ultrasound diagnostics indicate a high frequency of pathological changes in the liver parenchyma, the structure of the gall bladder and pancreas in peptic ulcer disease of the stomach and duodenum when Helicobacter Pylori is detected. Signs of cytolysis are observed in patients with peptic ulcer disease of the duodenum during Helicobacter Pylori. |
| Tags |
gastric ulcer disease,duodenal ulcer disease,chronic helicobacteriosis |
| Bibliography |
- Horyachkovsky AM. Klinichna biokhimiya v laboratorniy diahnostytsi. . 3rd. – Odesa: Ecology, 2005; 616. [in Ukrainian]
- Kharchenko АV, Yelinska AM, Shepitko VI, Stetsuk EV. Khronichnyy periodontyt u khvorykh na khronichnu vyrazkovu khvorobu dvanadtsyatypaloyi kyshky. Svit medytsyny ta biolohiyi. 2022; 1(79): 232–236. http://dx.doi.org/10.26724/2079-8334-2022-1-79-232-236 [in Ukrainian]
- Lapach SN, Chubenko AV, Babich PN. Statystychni metody v medyko-biolohichnykh doslidzhennyakh z vykorystannyam Excel. K.: Morion, 2000: 320. [in Ukrainian]
- Shukhtina IN, Gozhenko AI, Shukhtin VV, Kotiuzhynska SG, Avramenko AA, Badiuk NS, et al. plyv protydiabetychnykh preparativ na stan pechinky shchuriv pislya antykhelikobakternoyi terapiyi. Pharmacology On Line. 2021; 3: 1572–1584. https://pharmacologyonline.silae.it/files/archives/2021/vol3/PhOL_2021_3_A173_Shukhtina.pdf [in Ukrainian]
- Cherif S, Rais H, Hakmaoui A, Sellami S, Elantri S, Amine A. Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles. Bioinformation. 2019 Oct 31;15(10):735–743. doi: 10.6026/97320630015735. PMID: 31831956; PMCID: PMC6900325. [in Ukrainian]
- Gravina AG, Priadko K, Ciamarra P, Granata L, Facchiano A, Miranda A, et al. Extra-Gastric Manifestations of Helicobacter pylori Infection. J Clin Med. 2020 Nov 30; 9(12):3887. doi: 10.3390/jcm9123887. PMID: 33265933; PMCID: PMC7761397.
- Malfertheiner P, Camargo MC, El-Omar E, Liou JM, Peek R, Schulz C, et al.Helicobacter pylori infection. Nat Rev Dis Primers. 2023 Apr 20;9(1):19. doi: 10.1038/s41572-023-00431-8. PMID: 37081005.
- Popescu D, Andronescu D, Babes PA. The Association Between Helicobacter Pylori Infection and Liver and Biliary Tract Disorders. Curr Health Sci J. 2018 Apr-Jun;44(2):186–191. doi: 10.12865/CHSJ.44.02.16. Epub 2018 Mar 27. PMID: 30687530; PMCID: PMC6320469.
- Rabelo-Gonçalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World J Hepatol. 2015 Dec 28;7(30):2968–79. doi: 10.4254/wjh.v7.i30.2968. PMID: 26730276; PMCID: PMC4691700.
- Santos MLC, de Brito BB, da Silva FAF, Sampaio MM, Marques HS, Oliveira E Silva N, et al. Helicobacter pylori infection: Beyond gastric manifestations. World J Gastroenterol. 2020 Jul 28;26(28):4076–4093. doi: 10.3748/wjg.v26.i28.4076. PMID: 32821071; PMCID: PMC7403793.
- Song T, Sun R, Guo X, Qi X Characteristics of peptic ulcer in military officers/soldiers: a preliminary analysis. AME Med J 2018; 3:78 doi: 10.21037/amj.2018.07.05
- Yang H, Hu B. Diagnosis of Helicobacter pylori Infection and Recent Advances. Diagnostics (Basel). 2021 Jul 21;11(8):1305. doi: 10.3390/diagnostics11081305. PMID: 34441240; PMCID: PMC8391489.
|
| Publication of the article |
«World of Medicine and Biology» №3(85), 2023 year, 180-185 pages, index UDK 616.24-002.5-053.7-036.8:615 |
| DOI |
10.26724/2079-8334-2023-3-85-180-185 |
