| About the author: |
G. F. Stepanov, R. S. Vastyanov |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to assess the contractile proteins concentration and the dynamics of ATP-ase activity changes in striated and cardiac muscles of irradiated animals descendents. 130 1-month-old rats were divided into 3 groups in accordance to the dose of ionizing radiation given to them and theirs parents. The heart and the frontal group of thigh muscles were removed in which the contractile muscle proteins concentration and the muscle ATP-ase activity were determined. The ionizing radiation influence causes a disturbance in skeletal and cardiac muscles functioning in irradiated animals’ descendents manifested by muscle structure structural unit dysfunction – the actomyosin junction and muscle contraction energy supply disturbance realized by ATP-ase enzymatic system activity significant decrease. A more alterative effect of ionizing radiation on the cardiac muscle has been proven. The authors proved that leading links in the body and the muscle system radiation damage pathogenesis are the muscles functional state dysfunction, metabolic resources degradation, biochemical processes inversion, depletion of the energy supply of the muscle contractile function and the contractile intramuscular apparatus disruption. The core mechanism for radiation-induced muscle dysfunctions pathogenetically oriented scheme of pharmacological correction realization should be radioprotective and muscle-protective efficacy which will provide the opportunity to restore destroyed biochemical, physiological, electrical, functional and regulatory processes and activate sanogenetic mechanisms. |
| Tags |
ionizing irradiation,descendents of irradiated animals,actin,myosin,troponin tropomyosin,ATPase activity,pathophysiological mechanisms |
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| Publication of the article |
«World of Medicine and Biology» №3(85), 2023 year, 230-236 pages, index UDK 61:577.1, 616-008.9:577.23:577.12:612.014.482-092.9 |
| DOI |
10.26724/2079-8334-2023-3-85-230-236 |
