| About the author: |
O. I. Tiron, K. F. Shemonayeva, V. B. Khanzhi, G. Yu. Shevchuk, S. L. Lyashenko, O. V. Onufryenko, M. R. Vastianov |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to determine the experimental animals’ thyroid gland ultrastructural changes throughout the thermal skin injury dynamics in condition of hyperosmolar lactoprotein with sorbitol solution injection. The provided ultramicroscopic studies have established the expressed hyperosmolar lactoprotein with sorbitol colloid solution corrective influence on thyroid gland ultrastructural changes induced by its burning. Hyperosmolar lactoprotein with sorbitol colloid solution administration results in normalization of thyroid gland morphological structure and ultramicroscopic intrathyroidal disorders during the post-burn period. A significant improvement of thyroid blood capillaries and follicular cells ultrastructure was established in the dynamics of the trial with the normalization of their morphology at the ultrastructural level in the late stages of the thyroid gland post-burn period. Initial lactoprotein with sorbitol solution protective effects were registered on the 3rd day after thyroid gland burning. The most expressed lactoprotein with sorbitol protective effects were registered from the 21st day of the trial which were continued till the end. Therefore, the obtained data concerning the lactoprotein with sorbitol solution protecting efficacy in thyroid burning have a pathogenetic background which we consider as the experimental confirmation of hyperosmolar colloidal solutions clinical efficacy testing reasonability in thyroid gland parenchyma burn lesions. |
| Tags |
thyroid gland,thermal injury,ultrastructural changes,lactoprotein with sorbitol,pharmacocorrection,pathogenetic background |
| Bibliography |
- Vastyanov RS, Stoyanov AN, Bakumenko IK. Sistemnaya patologicheskaya dezintegratsiya pri khronicheskoy ishemii mozga. Eksperimentalno-klinicheskiye aspekty. Saarbrucken : LAP Lambert Academic Publishing. 2015: 169 [In Russian]
- Vastyanov RS, Stoyanov AN, Demidov VM, Bylsky DV, Antonenko SA, Nescoromnaya NV et al. Povrezhdeniya travmaticheskogo i gipoksicheskogo geneza: obshchnost' patogeneticheskikh mekhanizmov. Journal of Education, Health and Sport. 2016; 6(9): 285–304. doi http://dx.doi.org/10.5281/zenodo.61768. [In Russian]
- Volokhova GA, Stoyanov AN, Vastyanov RS. Antioksidantnyye effekty solkoserila pri eksperimentalnoy cherepno-mozgovoy travme. Mezhdunarodnyy nevrololgicheskiy zhurnal. 2008: 56–68 [In Russian]
- Horalskyy LP, Khomych VT, Kononskyy OI. Osnovy histolohichnoyi tekhniky i morfofunktsionalni metody doslidzhen u normi ta pry patolohiyi. Zhytomyr : ZhNAEU, 2019: 286 [In Ukrainian]
- Nebesna ZM, Yeroshenko GA. Histolohichni ta histokhimichni zminy lehen pry eksperymentalniy termichniy travmi. Svit medytsyny ta biolohiyi. 2015; 2(49) :106–110 [in Ukrainian]
- Dzevulska ІV, Kovalchuk ОІ, Cherkasov EV, Majewskyi ОYe, Shevchuk YuG, Pastukhova VA, Kyselova TM. Influence of lactoproteinum solution with sorbitol on DNA content of cells of endocrine glands on the background of skin burn in rats. World of Medicine and Biology. 2017; 2(64): 33–39. doi:10.26724/2079-8334-2018-2-64-33-39.
- Gavryluk AO, Galunko GM, Chereshniuk IL, Tikholaz VO, Cherkasov EV, Dzevulska1 ІV, et al Indicators cell cycle and DNA fragmentation in cells of small intestine mucosa 14, 21 and 30 days after skin burns on the background of preliminary infusion of solution lactoprotein with sorbitol or HAES-LX 5% World of medicine and biology. 2018; 1(63): 33–39. doi 10.26724 / 2079-8334-2017-4-62-104-108
- Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nat Rev Dis Primers. 2020; 6(1):11. doi: 10.1038/s41572-020-0145-5.
- Korkmaz HI, Flokstra G, Waasdorp M, Pijpe A, Papendorp SG, de Jong E, Rustemeyer T. et al. The Complexity of the Post-Burn Immune Response: An Overview of the Associated Local and Systemic Complications. Cells. 2023; 12(3): 345. doi: 10.3390/cells12030345
- Moroz VM, Shandra OA, Vastyanov RS, Yoltukhivsky MV, Omelchenko OD. Physiology. Vinnytsya : Nova Knyha, 2016: 722.
- Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG. Burns: Pathophysiology of Systemic Complications and Current Management. J Burn Care Res. 2017; 38(1): 469–481. doi: 10.1097/BCR.0000000000000355.
- Rae L, Fidler P, Gibran N. The Physiologic Basis of Burn Shock and the Need for Aggressive Fluid Resuscitation. Crit Care Clin. 2016; 32(4): 491–505. doi: 10.1016/j.ccc.2016.06.001.
- Stanojcic M, Abdullahi A, Rehou S, Parousis A, Jeschke MG. Pathophysiological Response to Burn Injury in Adults. Ann. Surg. 2018; 267: 576–584. doi: 10.1097/SLA.0000000000002097.
- Tiron OI, Herasimenko OS, Nikogosyan LR, Nescoromna NV, Merlich SV, Rusalkina LG et al. White rats thyroid gland morphological changes throughout the experimental thermal injury in conditions of lactoprotein with sorbitol hyperosmolar solutions administration // World of Medicine and Biology. 2023; 1 (83) 233–238. doi: 10.26724/2079-8334-2023-1-83-233-238
- Tiron OI, Vastyanov RS, Shapovalov VYu, Yatsyna OI, Kurtova MM. Pathophysiological mechanisms of thyroid gland hormonal dysregulation during experimental thermal exposure. World of Medicine and Biology 2022; 4(82): 246–251. doi: 10.26724/2079-8334-2022-4-82-246-251
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| Publication of the article |
«World of Medicine and Biology» №3(85), 2023 year, 243-247 pages, index UDK |
| DOI |
10.26724/2079-8334-2023-3-85-243-247 |
