| About the author: |
F. G. Sadikhov |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to conduct a morphological analysis of autoimmune changes in the thyroid gland in patients with autoimmune thyroiditis who received various treatment methods. The work is based on 481 patients' treatment results, including surgical and diagnostic material. Using data from fine-needle aspiration puncture biopsy and cytological examination of punctate samples, the nature of cytological changes in the thyroid gland was assessed. The diffuse-nodular form of autoimmune thyroiditis is characterized in most patients by an autoimmune process with goiter changes manifested by nodular and multinodular encapsulated formations. Outside of goiter changes, atrophic and sclerotic changes in the parenchyma and stroma of the gland, lymphoplasmacytic infiltration and oxyphilic cell transformation of the follicular epithelium are detected. Smaller transitional forms of B cells are observed in the foci of oxiphilic cell transformation. In the diffuse-pseudonodular form of autoimmune thyroiditis, the described changes persist in most patients but with less frequency (54.7–68 %). |
| Tags |
autoimmune thyroiditis,cytological changes,fine-needle aspiration biopsy |
| Bibliography |
- Abrosimov AYu. Novaya mezhdunarodnaya gistologicheskaya klassifikatsiya opukholey shchitovidnoy zhelezy. Arkhiv patologii. 2018;80(1):37–45. doi.org/10.17116/patol201880137-45 [In Russian]
- Bobyrova LYe, Muravlova OV, Horodynska OYu. Pryntsypy dyferentsiy̆ovanoï terapiï autoimunnoho tyreoïdytu zalezhno vid kharakteru metabolichnykh porushen. Visn. VDNZU «Ukraïnsʹka medychna stomatolohichna akademiya». 2014;14(1):28–34. [in Ukrainian]
- Vanushko VY, Beltsevich DG, Melnichenko GA, Rumyantsev PO, Fadeyev VV. PROYEKT: Klinicheskiye rekomendatsii Rossiyskoy assotsiatsii endokrinologov po diagnostike i lecheniyu uzlov shchitovidnoy zhelezy. Endokrinnaya khirurgiya. 2015;9(1):15–21. doi.org/10.14341/serg2015115-21 [In Russian]
- Djikaev GD. Osobennosti limfotsitarnoy infiltratsii shchitovidnoy zhelezy pri ochagovom i autoimmunnom tireoidite. Fundamentalnyye issledovaniya. 2014;10(3):498–500. https://fundamental-research.ru/ru/article/view?id=35450. [In Russian]
- Muravleva AV. Autoimunnyy tyreoyidyt ta yoho vuzlovi formy v strukturi suchasnoyi klinichnoyi tyreoyidopatiyi. Svit medytsyny ta biolohiyi. 2014;47(4):50–52. http://repository.pdmu.edu.ua/handle/123456789/18525 [in Ukrainian]
- Shidlovsky VA, Shidlovsky AV, Sheremet VI, Tverdokhleb VI. Tyreoyidyt Khashymoto – terapevtychna chy khirurhichna problema? (Ohlyad literatury). Mìžnarodnij endokrinologìčnij žurnal. 2020;16(3):245–250. doi.org/10.22141/2224-0721.16.3.2020.205274.8. [in Ukrainian]
- Sheremet MÍ, Sidorchuk LP, Shidlovskiy VO, Bedenyuk AD, Pashkovskaya NV, Leonova MO i dr. Novyye prognosticheskiye markery uzlovykh form zoba v sochetanii s autoimmunnym tireoiditom. Zhurnal obrazovaniya, zdorov'ya i sporta. 2017;7(3): 475–482 eISSN 2391-8306. doi.org/10.5281/zenodo.399322. [in Ukrainian]
- Agayev RM, Sadikhov FG, Aliyev FK. Evaluation of immunological changes in patients with diffuse form of autoimmune thyroiditis during laser photodynamic therapy. Bulletin of Surgery in Kazakhstan. 2021;4(69):32–37. doi.org/10.35805/BSK2021IV03
- Kang S, Kang J, Shen H, Wu N. Advances in regulatory B cells in autoimmune thyroid diseases. Review. Int. Immunopharmacol. 2021; 96:107770. doi: 10.1016/j.intimp.2021.107770.
- Kholová I, Kalfert D, Lintusaari J, Rajakorpi E, Ludvíková M. Follicular epithelial dysplasia as Hashimoto thyroiditis – related atypia: a series of 91 specimens. Endocrine Pathology. 2021;32(3):368–374. doi.org/10.1007/s12022-021-09679-w.
- Raess PW, Habashi A, El Rassi E, Milas M, Sauer DA, Troxell ML. Overlapping morphologic and immunohistochemical features of Hashimoto thyroiditis and IgG4-Related thyroid disease. Endocr Pathol.2015;26(2):170–177. doi.org/10.1007/s12022-015-9368-5
- Ralli M, Angeletti D, Fiore M, D'Aguanno V, Lambiase A, Artico M et al. Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation. Autoimmun Rev.2020;19(10):102649. doi.org/10.1016/j.autrev.2020.102649.
- Sadikhov FG. Immunohistochemical characteristics of thyroid gland changes in patients with autoimmune thyroiditis. World of medicine and biology. 2023;84(2):139–143. doi.org/10.26724/2079-8334-2023-2-84-139-143
- Sheremet MI, Sydorchuk LP, Shidlovskyi VO, Desiateryk VI, Kovalenko AE, Shevchenko SI et al. The activity of proliferation and apoptosis of thyrocytes in the thyroid tissue of patients of nodular goiter with autoimmune thyroiditis considering the polymorphism of the BCL-2 (RS17759659), CTLA-4 (RS231775), APO-1/FAS (RS2234767) genes. Biointerface Research in Applied Chemistry. 2020;10(2):5201–5208. doi.org/10.33263/BRIAC102.201208
- Yanhua B, Kennichi K, Chan K J. Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification. Endocrinol Metab (Seoul). 2020;35(4):696–715. doi: 10.3803/EnM.2020.807.
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| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 137-142 pages, index UDK 616.08-035 |
| DOI |
10.26724/2079-8334-2023-4-86-137-142 |
