| About the author: |
M. Y. Sokolov, D. I. Besh |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Xenobiotics are significant risk factor for the development of acute myocardial infarction. To elucidate the influence of xenobiotics on the course of ST segment elevation myocardial infarction and the peculiarities of intracoronary thrombi structure. 100 patients (mean age 57.81±10.26 years) with ST segment elevation myocardial infarction were included. All participants underwent manual thromboaspiration during percutaneous coronary intervention. Thrombi were evaluated morphologically. Patients with exposure to xenobiotics were significantly younger (55.29±10.86 vs. 61.25±11.14 years; P<0.008), more often had male gender (48 [92.3 %] vs. 34 [70.8 %]; P=0.005), and were smokers (35 [67.3 %] vs. 22 [45.8 %]; P=0.03). Іntracoronary thrombi of these patients less frequently demonstrated peripheral inflamation (22 (44 %) vs. 31 (66 %), p=0.030). Patients with occupational exposure to xenobiotics were more often males of younger age. The intracoronary thrombi of these patients rarely demonstrated signs of inflammation. |
| Tags |
myocardial infarction,blood clot,percutaneous coronary revascularization,xenobiotics |
| Bibliography |
- Zerbino DD, Solomenchuk TM. Infarkt miokarda v osib vikom menshe 50 rokiv: kliniko-patomorfolohichni osoblyvosti. Ukrayinskyy kardiolohichnyy zhurnal. 2006; 4 :90–96 [in Ukrainian]
- Svitlyk HV. Vplyv ksenobiotykiv na perebih hostroho infarktu miokarda. Svit Medytsyny ta Biolohiyi. 2018; 1(63) :69–74 doi 10.26724/2079-8334-2018-1-63-69-74 [in Ukrainian]
- Sokolov MYu. Reyestr perkutannykh koronarnykh vtruchan: rozshyrenyy porivnyalnyy analiz rezultativ 2016 i 2017 roku. Vid reperfuziynoho paradoksu do znyzhennya letalnosti. Sertse i sudyny. 2018;3:9–27.doi: https://doi.org/10.30978/HV2018-3-9 [in Ukrainian]
- Canfield J, Totary-Jain H. 40 Years of Percutaneous Coronary Intervention: History and Future Directions J. Pers. Med. 2018; 8(4) :33. doi: 10.3390/jpm8040033
- Frоbert O, Lagerqvist B, Olivecrona GK, Omerovic E, Gudnason T., Maeng M, et al. Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction. N Engl J Med. 2013; 369 (17):1587–1697. doi : 10.1056/NEJMoa1308789
- Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST- segment elevation of the European Society of Cardiology (ESC). EurHeart J. 2018; 39(2): 119–177. https://doi.org/10.1093/eurheartj/ehx393
- Lim SY. No-Reflow Phenomenon by Intracoronary Thrombus in Acute Myocardial Infarction. Chonnam Medical Journal. 2016; 52(1) :38–44. doi: 10.4068/cmj.2016.52.1.38O
- Pietrzykowski Ł, Michalski P, Kosobucka A, Kasprzak M, Fabiszak T, Stolarek W, et al. Medication adherence and its determinants in patients after myocardial infarction. Sci Rep. 2020; 10(1) :12028. doi: 10.1038/s41598-020-68915-1.
- Soldati S, Di Martino M, Rosa AС, Fusco D, Davoli M, Mureddu GF. The impact of in-hospital cardiac rehabilitation program on medication adherence and clinical outcomes in patients with acute myocardial infarction in the Lazio region of Italy. BMC Cardiovasc Disord. 2021; 21(1) :466. doi: 10.1186/s12872-021-02261-6.
- Svitlyk H, Harbar M, Salo V, Kapustynskyy O, Svitlyk Y. Occupational hazards as a risk factor of onset and unfavorable outcome of ischemic heart disease. Georgian Med. News. 2018; 275(2): 132–141. https://pubmed.ncbi.nlm.nih.gov/29578439/
- Teslenko YV, Myakinkova LO, Teslenko MM. Early cardiac rehabilitation in acute myocardial infarction patients and its features. World of Medicine and Biology. 2021; №4(78) :166–171. doi: 10.26724/2079-8334-2021-4-78-166-171
- Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth universal definition of myocardial infarction 2018. EurHeart J. 2019; 40(3) :237–269. https://doi.org/10.1093/eurheartj/ehy462
- Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, et al. Heart Disease and Stroke Statistics-2022 Update: A Report from the American Heart Association. Circulation. 2022; 145(8): 153–639. doi: 10.1161/CIR.0000000000001052
- World Health Organization. Cardiovascular diseases [Internet]. 11 June 2021. Available from: https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
|
| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 157-162 pages, index UDK 616.127-005.8+616.132.2-005.6-018)-036-06:615.099 |
| DOI |
10.26724/2079-8334-2023-4-86-157-162 |
