| About the author: |
O. P. Yavorovsky, V. M. Riabovol, T. O. Zinchenko, M. M. Zahornyi, A. V. Ragulya, O. M. Lavrynenko, O. Yu. Povnitsa |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The structural-morphological, toxicological, cytotoxic, and virucidal properties of photoelectronic TiO2 and TiO2-Ag were investigated to ascertain safety concerns related to their production and application. It was demonstrated that the TiO2-Ag nanocomposite exhibits an anatase crystalline modification and is composed of TiO2 nanoparticles ranging from 13 to 20 nm and Ag nanoparticles with sizes of 35–40 nm, with silver localized on the surface of titanium dioxide. LD50 values were established as 4783.30 mg/kg for nano-TiO2 and 724.44 mg/kg for nano-TiO2-Ag after acute intraperitoneal administration of nanopowders to mice. Accumulation of TiO2 and TiO2-Ag nanopowders was observed, causing damage to the livers, kidneys, and lungs of laboratory animals. TiO2-Ag and TiO2 nanomaterials could potentially induce chronic inflammation and allergic reactions in synthesis operators. These nanomaterials affected the activity of mitochondrial enzymes in testicular cells of boars, exerting a damaging effect on mitochondrial membranes and cells overall. Silver modification of nano-TiO2 led to reduced toxicity of nanoparticles for BHK-21 and MDCK cells. Significant virucidal effects of TiO2-Ag and TiO2 nanoparticles were demonstrated. |
| Tags |
titanium dioxide nanoparticles,toxicology,mechanism of action,cytokines,nanomaterials,oxidative enzymes,cytotoxicity,virucidal action |
| Bibliography |
- Yavorovsky OP, Zazuliak TS, Ostapiv DD, Riabovol VM, Demetska OV. Comparative assessment of the effect of titanium dioxide – based nanoparticles on boar germ cells in vitro. Medycni perspectivy. 2022; 27(4) :13–19. doi: 10.26641/2307-0404.2022.4.271117. [in Ukrainian]
- Chaktouna U, Benseid H, Zari N, Qaiss A, Bouhfid R. Recent progress on Ag/TiO2 photocatalysts: photocatalytic and bactericidal behaviours. Environ Sci Pollut Res Int. 2021; 28(33) :44638–44666. doi: 10.1007/s11356-021-14996-y.
- De Oliveira, IN., Oliveira RIS, Pereira EB, Padilha FF, Egues SM, & Hernández-Macedo ML. Synthesis and photocatalytic effects of TiO2-Ag on antibiotic-resistant bacteria. Peer Review. 2023; 5(8) :45–61. https://doi.org/10.53660/400.prw1014B.
- Deshmukh SP, Mullani SB, Koli VB, Patil SM, Kasabe PJ, Dandge PB, Delekar SD. Ag Nanoparticles Connected to the Surface of TiO2 Electrostatically for Antibacterial Photoinactivation Studies. Photochem Photobiol. 2018; 94(6) :1249–1262. doi:10.1111/php.12983.
- Ellouzi I, Bouddouch B, Bakkiz B, Benlhachemi A, Qualid HA.Glucose-assisted ball milling preparation of silver-doped biphasic TiO2 for efficient photodegradation of Rhodamine B: Effect of silver-dopant loading. Chem Phys Let. 2021; 770 :38456. doi: 10.1016/j.cplett.2021.138456.
- Khan MM, Matussin SN, & Rahman A. Recent development of metal oxides and chalcogenides as antimicrobial agents. Bioprocess Biosyst Eng. 2023; 46(9) :1231–1249. doi: 10.1007/s00449-023-02878-1.
- Lavrynenko O M, Zahornyi MM, Vember VV, Pavlenko OY, Lobunets TF, Kolomys OF, Povnitsa OY et al. Nanocomposites Based on Cerium, Lanthanum, and Titanium Oxides Doped with Silver for Biomedical Application. Cond. Mat. 2022; 7(3) :45. doi: 10.3390/condmat7030045.
- Povnitsa O, Zahorodnia S, Artiukh L, Zahornyi M, Ievtushenko A. Photodynamic Treatment of Titanium Dioxide Nanoparticles is a Convenient Method of Adenoviral Inactivation. Mikrobiological Journal. 2023; 85(3) :61–69. doi: 10.15407/ microbiolj85.03.061.
- Stoian M, Kuncser A, Neatu F, Florea M, Popa M, Voicu SN, et al. Green synthesis of aminated hyaluronic acid-based silver nanoparticles on modified titanium dioxide surface: Influece of size and chemical composition on their biological properties. Internat J Biolog Macromol. 2023; 253 :127445. doi: 10.1016/j.ijbiomac.2023.127445.
- Sukitpong J, Chiarakorn S. Degradation of acetaldehyde by Ag/TiO2 photocatalyst coated on the polyester air filter. IOP Conf. Ser.: Earth Environ. Sci 2019; 373 :012020. doi:10.1088/1755-1315/373/1/012020.
- Vazhnichnaya EM, Lutsenko RV, Semaka OV, Deviatkina TO, Deviatkina NM, Karpov VA et al. Blood gases and electrolytes under use of magnetite nanoparticles in blood loss. World of Medicine and Biology. 2021; 77(3) :194–198. doi: 10.26724/2079-8334-2021-3-77-194-198.
- Zheng Z, Murakamia N, Liu J, Teng Z, Zhang Q, Cao Y, Ohno T. Development of plasmonic photocatalyst by site-selective loading of bimetallic nanoparticles of Au and Ag on Titanium (IV). Chem Cat Chem. 2020; 12(14) :3783–3792. doi: 10.1002/cctc.202000366.
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| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 181-186 pages, index UDK 613.63:615.9:661.882’022-14-022.513.2 |
| DOI |
10.26724/2079-8334-2023-4-86-181-186 |
