| About the author: |
O. M. Grabovyi, N. M. Nevmerzhytska, S. E. Shepelev, H. Yu. Kondaurova |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Regenerative neuroma of the sciatic nerve is characterized by typical cellular composition and the Schwann cells and fibroblasts ratio. Dexamethasone or granulocyte colony-stimulating factor applied in the early stages of regenerative neuroma formation affects the final state of the stromal component of the neuroma and slightly increases Schwann cells in it. The combined use of dexamethasone and granulocyte colony-stimulating factor potentiates the effect of granulocyte colony-stimulating factor on increasing the number of Schwann cells in the regenerative neuroma and delays its involution. It leads to a noticeable change in the regenerative neuroma composition towards the neural component. |
| Tags |
sciatic nerve,regenerative neuroma,nerve injury,fibroblast,Schwann cells |
| Bibliography |
- Aschauer-Wallner S, Leis S, Bogdahn U, Johannesen S, Couillard-Despres S, Aigner L. Granulocyte colony-stimulating factor in traumatic spinal cord injury. Drug Discov Today. 2021;26(7):1642–1655. doi:10.1016/j.drudis.2021.03.014
- Charoenlux P, Utoomprurkporn N, Seresirikachorn K. The efficacy of corticosteroid after facial nerve neurorrhaphy: a systematic review and meta-analysis of randomized controlled trial. Braz J Otorhinolaryngol. 2023;89(1):79–89. doi:10.1016/j.bjorl.2021.09.005
- Choi SY, Kim JM, Jung J, Park DC, Yoo MC, Kim SS, et al. Review of Drug Therapy for Peripheral Facial Nerve Regeneration That Can Be Used in Actual Clinical Practice. Biomedicines. 2022;10(7):1678. Published 2022 Jul 12. doi:10.3390/biomedicines10071678
- Feng X, Yuan W. Dexamethasone enhanced functional recovery after sciatic nerve crush injury in rats. Biomed Res Int. 2015; 2015:627923. doi.org/10.1155/2015/627923
- Gao W, Tong D, Li Q, Huang P, Zhang F. Dexamethasone promotes regeneration of crushed inferior alveolar nerve by inhibiting NF-κB activation in adult rats. Arch Oral Biol. 2017;80:101–109. doi:10.1016/j.archoralbio.2017.03.025
- Gordon T, Borschel GH. The use of the rat as a model for studying peripheral nerve regeneration and sprouting after complete and partial nerve injuries. Exp Neurol. 2017;287(Pt 3):331–347. doi:10.1016/j.expneurol.2016.01.014
- Lee JI, Hur JM, You J, Lee DH. Functional recovery with histomorphometric analysis of nerves and muscles after combination treatment with erythropoietin and dexamethasone in acute peripheral nerve injury. PLoS One. 2020;15(9):e0238208. Published 2020 Sep 3. doi:10.1371/journal.pone.0238208
- Li R, Li DH, Zhang HY, Wang J, Li XK, Xiao J. Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration. Acta Pharmacol Sin. 2020;41(10):1289–1300. doi:10.1038/s41401-019-0338-1
- Morisaki S, Nishi M, Fujiwara H, Oda R, Kawata M, Kubo T. Endogenous glucocorticoids improve myelination via Schwann cells after peripheral nerve injury: An in vivo study using a crush injury model. Glia. 2010;58(8):954-963. doi:10.1002/glia.20977
- Svyrydiuk RV, Shepitko KV, Shepitko VI, Raskalei TYa. Morphometric characteristics of the sciatic nerve trunk in the acute aseptic inflammation in rats. World of Medicine and Biology. 2018; 2(64): 173–175. DOI: 10.26724/2079-8334-2018-2-64-173-175
- Seth R, Revenaugh PC, Kaltenbach JA. Facial nerve neurorrhaphy and the effects of glucocorticoids in a rat model. Otolaryngol Head Neck Surg. 2012;147(5):832–840. doi:10.1177/0194599812451551
- Sun H, Yang T, Li Q. Dexamethasone and vitamin B (12) synergistically promote peripheral nerve regeneration in rats by upregulating the expression of brain-derived neurotrophic factor. Arch Med Sci. 2012;8(5):924–930. doi:10.5114/aoms.2012.31623
- Sumarwoto T, Suroto H, Mahyudin F. Role of adipose mesenchymal stem cells and secretome in peripheral nerve regeneration. Ann Med Surg (Lond). 2021;67:102482. Published 2021 Jun 9. doi:10.1016/j.amsu.2021.102482
- Tsymbaliuk VI, Kuchyn YuL, Lurin IA, Strafun SS, Graboviy OM, Gumenyuk KV, et al. Study of gunshot injuries features of peripheral nerves by modern weapons in the experiment. World of Medicine and Biology. 2022. 3 (81): 242–247. doi:10.26724/2079-8334-2022-3-81-242-247
- Uzun T, Toptas O, Saylan A, Carver H, Turkoglu SA. Evaluation and Comparison of the Effects of Artesunate, Dexamethasone, and Tacrolimus on Sciatic Nerve Regeneration. J Oral Maxillofac Surg. 2019;77(5):1092.e1–1092.e12. doi:10.1016/j.joms.2018.12.019
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| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 187-192 pages, index UDK 616.833.58-003:93-006-091:57.042 |
| DOI |
10.26724/2079-8334-2023-4-86-187-192 |
