| About the author: |
A. V. Yuhimchuk, N. I. Voloshchuk, S. Yu. Shtrygol’, O. O. Nefodov, V. V. Piliponova, Yu. M. Oliinyk, A. M. Tepla, O. O. Nefodova |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the study was to assess sex-specific changes in the production of vasoactive molecules during experimental acute cold injury and to investigate endotheliotropic mechanisms that ensure the formation of the body's sex-determining response to the frigoprotective effect of glucosamine. Changes in the production of vasoconstrictor molecules (endothelin-1, adhesion molecules of cranial cellin-1 and vasodilating molecules (H2S, NO) and markers of oxidative stress (nicotinamide adenine dinucleotide phosphate oxidase, superoxide dismutase) in rats of different sexes and the effect on these parameters of prophylactic and therapeutic administration of glucosamine (50 mg/kg intragastrically) were studied on the model of acute cold injury. It was established that acute cold injury causes an increase in the activity of nicotinamide adenine dinucleotide phosphate oxidase, a decrease in the activity of superoxide dismutase in animals of both sexes, an increase in the content of vasoconstrictors and a decrease in the production of vasodilating molecules, to a greater extent in male animals. The endothelial dysfunction degree and oxidative stress's expressiveness in females were statistically lower. Therapeutic and prophylactic administration of glucosamine reduces the severity of pathological changes in the body of animals caused by acute cold injury to a greater extent in male rats. The degree of expressiveness of sex differences in the indicators studied remains. However, the difference in indicators between animals of different sexes decreases. |
| Tags |
cold injury,gender differences,rats,glucosamine,vasoactive molecules,hydrogen sulfide,nitrogen monoxide,oxidative stress |
| Bibliography |
- Bondariev YeV. Eksperymentalne obgruntuvannia optymizatsiyi profilaktyky ta likuvannia kholodovoyi travmy zasobamy metabolitotropnoyi ta protyzapalnoyi diyi [dysertatsiya]. Kharkiv: Nats. Farm. un-t. 2020; 45 s. [in Ukrainian]
- Bondariev YeV. Fryhoprotektorni ta antyoksydantni vlastyvosti preparativ hliukozaminu ta atsetylsalitsylovoyi kysloty v umovakh hostroyi lokalnoyi kholodovoyi travmy. Ukrainskyi biofarmatsevtychnyi zhurnal. 2018; 1(54):18–24. [in Ukrainian]
- Bondariev YeV, Shtryhol SIu, Drohovoz SM, Shchokina KH. Kholodova travma: doklinichne vyvchennia likarskykh preparativ z fryhoprotektornymy vlastyvostiamy. Metodychni rekomendatsii MOZ Ukrainy, m. Kharkiv. Natsionalnyi farmatsevychnyi universytet. 2018; 35 s. [in Ukrainian]
- Melnyk AV. Statevi osoblyvosti rivnia hidrohen sulfidu v syrovattsi krovi shchuriv. Visnyk morfolohiyi. 2017; 1(23):7–9. [in Ukrainian]
- Pelypenko OV, Shepitko VI, Pelypenko LB. Morfofunktsionalna kharakterystyka mikrotsyrkuliatornoho rusla subkhondralnoyi kistky pry vvedenni kriokonservovanoyi platsenty na tli aseptychnoho zapalennia suhlobu u shchuriv. Svit medytsyny ta biolohiyi. 2019; 2(68):187–191. [in Ukrainian]
- Anand P, Privitera R, Yiangou Y, Donatien P, Birch R, Misra P. Trench Foot or Non-Freezing Cold Injury As a Painful Vaso-Neuropathy: Clinical and Skin Biopsy Assessments. Front Neurol. 2017; 8:514. https://doi.org/10.3389/fneur.2017.00514.
- Endorf FW, Nygaard RM. High Cost and Resource Utilization of Frostbite Readmissions in the United States. J Burn Care Res. 2021 Sep 30;42(5):857–864 https://doi.org/10.1093/jbcr/irab076.
- Hristov KL, Parajuli SP, Provence A, Rovner ES, Petkov GV. Nongenomic modulation of the large conductance voltage- and Ca2+-activated K+ channels by estrogen: A novel regulatory mechanism in human detrusor smooth muscle. Physiol Rep. 2017 Jul;5(14):e13351. doi: 10.14814/phy2.13351
- Ma J, Li Y, Yang X, Liu K, Zhang X, Zuo X, Ye R, et al. Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther. 2023 Apr 20;8(1):168. doi: 10.1038/s41392-023-01430-7.
- McIntosh SE, Freer L, Grissom CK, Auerbach PS, Rodway G W, Cochran A et al. Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update. Wilderness & Environmental Medicine. 2019; 30(4S): S19eS32. DOI: https://doi.org/10.1016/j.wem.2019.05.002.
- Moreau KL. Intersection between gonadal function and vascular aging in women. J Appl Physiol (1985). 2018 Dec 1;125(6):1881–1887. doi: 10.1152/japplphysiol.00117.2018
- Nagarajan S. Update: Cold weather injuries, active and reserve components, U.S. Armed Forces, July 2010-June 2015. MSMR. 2015 Oct;22(10):7–12.
- Nygaard R. M., Endorf F. W. Frostbite vs Burns: Increased Cost of Care and Use of Hospital Resources J Burn Care Res. 2018 Aug 17;39(5):676–679.
- Teoh JP, Li X, Simoncini T, Zhu D, Fu X. Estrogen-Mediated Gaseous Signaling Molecules in Cardiovascular Disease. Trends Endocrinol Metab. 2020 Oct;31(10):773–784. doi: 10.1016/j.tem.2020.06.001
- Xiang D, Liu Y, Zhou S, Zhou E, Wang Y. Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress. Oxid Med Cell Longev. 2021 Jun 28;2021:5523516. doi: 10.1155/2021/5523516.
|
| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 243-247 pages, index UDK 616-001.18:546.221.1+547.425.24]:159.944:159.923:639.028 |
| DOI |
10.26724/2079-8334-2023-4-86-243-247 |
