| About the author: |
O. M. Bilovol, I. I. Kniazkova, V. M. Mishchenko, V. P. Starenky, N. V. Kuzminova, A. V. Krivoshapko, L. P. Abramova |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of the work was to study the features of the diastolic function of the left ventricle and the tumor necrosis factor-α level in patients with combined pathology: arterial hypertension with type 2 diabetes and obesity. Disorders of the diastolic function of the left ventricle were established to be more often registered in patients with arterial hypertension with type 2 diabetes and obesity, compared to the group of patients with arterial hypertension and type 2 diabetes with normal body weight. A significant
increase in the content of tumor necrosis factor-α was determined in the group of patients with arterial hypertension with type 2 diabetes and obesity compared to the group with arterial hypertension and type 2 diabetes with normal body weight. |
| Tags |
arterial hypertension,type 2 diabetes,diastolic dysfunction,tumor necrosis factor-α |
| Bibliography |
- Alzamil H. Elevated Serum TNF-α Is Related to Obesity in Type 2 Diabetes Mellitus and Is Associated with Glycemic Control and Insulin Resistance. J Obes. 2020; 2020: 5076858. doi: 10.1155/2020/5076858.
- Borghetti G, von Lewinski D, Eaton DM, Sourij H, Houser SR, Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control Front Physiol. 2018; 9: 1514. doi: 10.3389/fphys.2018.01514
- Bräuninger H, Thottakara T, Schön J, Voss S, Dhople V, Warnke S. Cytokine-Mediated Alterations of Human Cardiac Fibroblast's Secretome. Int J Mol Sci. 2021; 22(22): 12262. doi: 10.3390/ijms222212262.
- Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V. ESC Scientific Document Group. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD Eur Heart J. 2020; 41(2): 255–323. doi: 10.1093/eurheartj/ehz486.
- Gosmanov AR, Lu JL, Sumida K, Potukuchi PK, Rhee CM, Kalantar-Zadeh K. Synergistic association of combined glycemic and blood pressure level with risk of complications in US veterans with diabetes. J. Hypertens. 2016; 34: 907–913. doi: 10.1097/HJH.0000000000000864.
- Hsuan CF, Teng SIF, Hsu CN, Liao D, Chang AJ, Lee HL. Emerging Therapy for Diabetic Cardiomyopathy: From Molecular Mechanism to Clinical Practice. Biomedicines. 2023; 11(3): 662. doi: 10.3390/biomedicines11030662.
- Leão RN, Silva PM, Branco L, Fonseca H, Bento B, Alves M. Systolic time ratio measured by impedance cardiography accurately screens left ventricular diastolic dysfunction in patients with arterial hypertension. Clin. Hypertens. 2017; 23: 28.
- Lu J, Zhao J, Meng H, Zhang X. Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes. Front Immunol. 2019; 10: 1173. doi: 10.3389/fimmu.2019.01173.
- Price AJ, Crampin AC, Amberbir A, Kayuni-Chihana N, Musicha C, Tafatatha T. Prevalence of obesity, hypertension, and diabetes, and cascade of care in sub-Saharan Africa: a cross-sectional, population-based study in rural and urban Malawi. Lancet Diabetes Endocrinol. 2018; 6(3): 208–222. doi: 10.1016/S2213-8587(17)30432-1.
- Siegmund D, Zaitseva O, Wajant H. Fn14 and TNFR2 as regulators of cytotoxic TNFR1 signaling. Front Cell Dev Biol. 2023; 11: 1267837. doi: 10.3389/fcell.2023.1267837.
- Shaposhnyk OA, Prykhodko NP, Savchenko LV, Shevchenko TI, Sorokina SI, Yakymyshyna LI. Clinical and diagnostic aspects of managing patients with valvular heart disease World of Medicine and Biology. 2022; 2(80): 178–183. doi: 10.26724/2079-8334-2022-2-80-178-183
- Sundqvist MG, Sahlén A, Ding ZP, Ugander M. Diastolic function and its association with diabetes, hypertension and age in an outpatient population with normal stress echocardiography findings. Cardiovasc Ultrasound. 2020; 18(1): 46. doi: 10.1186/s12947-020-00228-9
- Tzanavari T, Giannogonas P, Karalis KP. TNF-alpha and Obesity. Curr Dir Autoimmun. 2010; 11: 145–156. doi: 10.1159/000289203.
- Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Bäck M. ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021; 42(34): 3227–3337. doi: 10.1093/eurheartj/ehab484.
- Worley E, Rana B, Williams L, Robinson S. Left ventricular diastolic dysfunction: identifying presence by left atrial function. Echo Res Pract. 2018; 5: 97–104. doi: 10.1530/ERP-18-0013
|
| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 015-019 pages, index UDK 616.12-008.331.1+616.379-008.64]-056.257:616.124.2-007.61 |
| DOI |
10.26724/2079-8334-2023-4-86-15-19 |
