| About the author: |
M. K. Ismayilova |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The purpose of our study was to assess the levels of immunological indicators in infertile patients with positive and negative results of in vitro fertilization procedure. The study of indicators of immune status was conducted in 54 married couples. The concentration of immunoglobulins A, M and G were tested by the radial immunodiffusion method. The main lymphocyte populations–T-lymphocytes, T-helpers, cytolytic T-cells, natural killers, B-lymphocytes against monoclonal antibodies, respectively, CD3, CD4, CD8, CD16, CD19, CD25, HLA-DR, CD4/CD8 were studied. Indicators of immune imbalance in both partners were found in 7 % of married couples (in men were determined in 9 % of cases, in women–in 15 % of cases). In infertile women the number of T-helpers significantly exceeds the indicators of men in both the main and control groups (р<0.001), a decrease in the number of T-suppressors was determined in infertile women compared to the indicators in men and the indicators in the control group. The level of IgM was significantly higher in women (3.7 g/l) than in men (2.4 g/l) of infertile couples and the control group (1.7 g/l), (р<0.05). There were no significant changes in the amount of IgA and IgG in patients in the observation groups. |
| Tags |
T-lymphocytes,natural killers,immunoglobulins,infertility |
| Bibliography |
- Azargoon A, Mirrasouli Y, Shokrollahi Barough M, Barati M, Kokhaei P. The State of Peripheral Blood Natural Killer Cells and Cytotoxicity in Women with Recurrent Pregnancy Loss and Unexplained Infertility. Int J Fertil Steril. 2019 Apr;13(1):12–17. doi: 10.22074/ijfs.2019.5503.
- Bukovsky A. Novel Immunological Aspects for the Treatment of Age-induced Ovarian and Testicular Infertility, Other Functional Diseases, and Early and Advanced Cancer Immunotherapy. Human Reproduction: Updates and New Horizons, 2017; 143–204, doi:10.1002/9781118849613.ch4
- Chernyshov VP, Dons'koi BV, Sudoma IO, Goncharova YO. Comparison of T and NK lymphocyte subsets between human endometrial tissue and peripheral blood. Cent Eur J Immunol. 2019;44(3):316–321. doi: 10.5114/ceji.2019.89610.
- Cimadomo D, Craciunas L, Vermeulen N, Vomstein K, Toth B. Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists. Hum Reprod. 2021 Jan 25;36(2):305–317. doi: 10.1093/humrep/deaa317.
- Diao L, Cai S, Huang C, Li L, Yu S, Wang L, et al. New endometrial immune cell-based score (EI-score) for the prediction of implantation success for patients undergoing IVF/ICSI. Placenta. 2020 Sep 15;99:180–188. doi: 10.1016/j.placenta.2020.07.025.
- Dons'koi BV. Accentuated hypo- and hyper-NK lymphocyte CD8 expression is a marker of NK subsets' misbalance and is predictive for reproductive failures. Immunobiology. 2015 May;220(5):649–55. doi: 10.1016/j.imbio.2014.11.015.
- Ho YK, Chen HH, Huang CC, Lee CI, Lin PY, Lee MS,et al. Peripheral CD56+CD16+ NK Cell Populations in the Early Follicular Phase Are Associated With Successful Clinical Outcomes of Intravenous Immunoglobulin Treatment in Women With Repeated Implantation Failure. Front Endocrinol (Lausanne). 2020 Jan 21;10:937. doi: 10.3389/fendo.2019.00937.
- Liang PY, Diao LH, Huang CY, Lian RC, Chen X, Li GG, et al. The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure. Reprod Biomed Online. 2015 Dec;31(6):823–6. doi: 10.1016/j.rbmo.2015.08.009.
- Mishchenko VP, Rudenko IV, Likhachov VK, Gromova AM, Tarasenko KV. Folate cycle drugs in the complex preventive therapy for the miscarriage. World of Medicine and Biology. 2021; 2(76): 093–098. doi:10.26724/2079-8334-2021-2-76-93-98
- Russell P, Sacks G, Tremellen K, Gee A. The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. III: Further observations and reference ranges. Pathology. 2013 Jun;45(4):393–401. doi: 10.1097/PAT.0b013e328361429b.
- Seshadri S, Sunkara SK. Natural killer cells in female infertility and recurrent miscarriage: a systematic review and metaanalysis. Hum Reprod Update. 2014 May-Jun;20(3):429–38. doi: 10.1093/humupd/dmt056.
- Shibahara H, Chen Y, Honda H, Wakimoto Y, Fukui A, Hasegawa A. Sex difference in anti-sperm antibodies. Reprod Med Biol. 2022 Jul 5;21(1):e12477. doi: 10.1002/rmb2.12477.
- Ticconi C, Inversetti A, Logruosso E, Ghio M, Casadei L, Selmi C, et al. Antinuclear antibodies positivity in women in reproductive age: From infertility to adverse obstetrical outcomes - A meta-analysis. J Reprod Immunol. 2023 Feb;155:103794. doi: 10.1016/j.jri.2022.103794.
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| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 061-064 pages, index UDK 618.177:618.145-07 |
| DOI |
10.26724/2079-8334-2023-4-86-61-64 |
