| About the author: |
I. O. Komarevtseva, Yu. A. Chernykh, R. V. Cherednichenko, I. I. Zielonyi, Yu. V. Brezhnyeva, V. N. Komarevtsev, I. V. Shipilova |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Spontaneous preterm birth is the leading cause of perinatal morbidity and mortality worldwide. This problem has become especially relevant in the COVID-19 era. The purpose of the study was to investigate the association between serum alpha-1-antitrypsin levels and premature birth in COVID-19 and healthy pregnant women. Our study showed that serum alpha- 1-antitrypsin levels increase during normal pregnancy. We found that changes in alpha-1-antitrypsin concentrations are an important factor in preterm birth. Namely, there is an inverse relationship between alpha-1 antitrypsin levels and preterm birth: the lower the serum alpha-1 antitrypsin level, the higher the risk of preterm birth. In this study, we found that non-pregnant women with COVID-19 had a lower of alpha-1-antitrypsin levels then healthy non-pregnant women. In group pregnant women with COVID-19 with preterm birth level of α1-AT was approximately 1.5-fold lower in pregnant women with COVID-19 with timely delivery. |
| Tags |
alpha-1-antitrypsin,preterm birth,COVID-19 |
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| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 086-091 pages, index UDK 616.61-006:616.65+576.367 |
| DOI |
10.26724/2079-8334-2023-4-86-86-91 |
