| About the author: |
I. O. Melnychuk |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The aim: to found out connections between platelets amino acids profile and cardiometabolic risk factors in coronary artery disease patients with atrial fibrillation. 300 patients were divided into 3 groups: first (I) – 149 patients with coronary artery disease and without arrhythmias, second (II) – 123 patients with coronary artery disease and atrial fibrillation paroxysm and 28 patients in control group. In II group in comparison with I group were checked (P<0.05): increasing isoleucine (10.73 %), leucine (12.63 %) and decreasing threonine (23.05 %), serine (5.06 %), glycine (32.21 %), valine (30.83 %) levels in platelets amino acids profile; elevation of apolipoprotein B (29.91 %), C-reactive protein (40.93 %), interleucine-6 (22.93 %), trimethylamine (16.13 %) and trimethylamine-N-oxide (57.54 %) levels and fall of trimethylamine / trimethylamine-N-oxide ratio (26.16 %). Majority of correlations were found between glycine (total number = 12), threonine (total number = 6), glutamate (total number = 6), valine (total number = 6) and cardiometabolic risk factors. Platelets glycine correlated with age (r=-0.305), body mass index (r=-0.351), total cholesterol (r=-0.304), low density lipoprotein (r=-0.348), apolipoprotein A1 (r=0.373), apolipoprotein B (r=-0.347), interleucine-6 (r=-0.315), trimethylamine-N-oxide (r=-0.654), trimethylamine / trimethylamine-N-oxide ratio (r=0.688), prothrombin index (r=0.317), activated partial thromboplastin time (r=-0.365) and fibrinogen (r=-0.396), P<0.05. |
| Tags |
coronary artery disease,atrial fibrillation,amino acids,blood platelets,cardiometabolic risk factors |
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| Publication of the article |
«World of Medicine and Biology» №4(86), 2023 year, 110-114 pages, index UDK 616.12-008.313.2 |
| DOI |
10.26724/2079-8334-2023-4-86-110-114 |
