| About the author: |
N. V. Kuzminova, V. O. Romanova, A. V. Ivankova, S. E. Lozinsky, I. I. Kniazkova, Yu. L. Shkarivskyi, O. L. Poberezhets |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The article presents the results of a study of lipid metabolism in healthy individuals with a burdened heredity for arterial hypertension and patients with stage II hypertension. Lipid metabolism was studied using standard lipidogram parameters, with additional determination of apolipoproteins B100 and A-1 and lipoprotein (a). It was noted that in the blood serum of healthy individuals with a burdened heredity for arterial hypertension, proatherogenic changes in lipid fractions occur, similar to those of patients with stage II hypertension. It is noteworthy that the level of Lp(a) in individuals with a hereditary predisposition to hypertension was 67.0 % higher than in the control group (p<0.001) and almost reached the “critical” level, at which the probability of developing cardiovascular disease increases. However, the levels of apolipoproteins B100 and A-1 in this group did not differ from those of the control group. Thus, our data indicate that people with hereditary hypertension experience unfavorable shifts in the lipid spectrum of the blood even earlier in the onset and development of hypertension, which suggests that they are genetically determined. |
| Tags |
hypertension,genetic predisposition,heredity for hypertension,lipid metabolism disorders,dyslipidemia,lipoprotein (a),apolipoprotein A-1,apolipoprotein B100 |
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| Publication of the article |
«World of Medicine and Biology» №4(90), 2024 year, 078-082 pages, index UDK 616.1:616.831-005:612.13:612.14:611.1:577.169:616.127:616.45-001.1/3 |
| DOI |
10.26724/2079-8334-2024-4-90-78-82 |
