| About the author: |
O. Ye. Akimov, A. O. Mykytenko, V. O. Kostenko, G. A. Yeroshenko |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
In recent years more attention has been paid to regulatory functions of connective tissue’s extracellular matrix. The aim of this study is to evaluate influence of NF-κB activation inhibitor on concentration of different fractions of glycosaminoglycans, L-hydroxyproline and sialic acids in rat heart during metabolic syndrome modelling. Research was conducted on 24 male Wistar rats weighing 190–260 g divided into 4 groups: control group; ammonium pyrrolidinedithicarbamate (PDTC) administration group; metabolic syndrome group (MetS group); combined administration of PDTC and MetS modelling group. Administration of PDTC during MetS modelling decreased total glycosaminoglycans, heparin-heparan and keratan-dermatan fraction concentration by 22.53 %, by 21.66 % and by 59.64 %, respectively, but increased chondroitin fraction by 62.1 % compared to MetS group. Concentration of L-hydroxyproline and sialic acids decreased by 26.95 % and by 17.37 %, respectively. Activation of nuclear transcription factor NF-κB in rat heart during metabolic syndrome modelling leads to increased intensity of extracellular matrix degradation. |
| Tags |
NF-κB,connective tissue,heart,glycosaminoglycans,L-hydroxyproline,metabolic syndrome |
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| Publication of the article |
«World of Medicine and Biology» №4(90), 2024 year, 154-157 pages, index UDK 616.12:612.015.3:612.08:599.323.4 |
| DOI |
10.26724/2079-8334-2024-4-90-154-157 |
