About the author: |
V. A. Synenko, G. A. Yeroshenko, K. V. Shevchenko, A. S. Grygorenko, V. V. Sokolenko, N. M. Sharlay, A. О. Vlasyuk |
Heading |
REVIEWS |
Type of article |
Scentific article |
Annotation |
This article examines the effects of the food additives sodium nitrite and Ponceau 4R on the retina. Both are widely used in the food industry to improve the taste, color, and shelf life of foods. However, their use has raised concerns among scientists and healthcare professionals about potential adverse health effects, particularly on the eyes. Sodium nitrite and its derivatives may cause oxidative stress and inflammation in the retina, which may lead to degenerative changes and vision loss. Although some studies suggest a neuroprotective effect of sodium nitrite, more research is needed to confirm these findings. Ponceau 4R may cause oxidative stress and inflammation in the retina, which may lead to damage to retinal pigment epithelial cells. This could potentially lead to vision loss and other eye problems. |
Tags |
retina,rats,sodium nitrite,Ponceau 4R,oxidative stress |
Bibliography |
- Donchenko SV, Bilash SM, Severyn YuM. Vplyv naiposhyrenishykh kharchovykh dobavok na zdorovia liudyny. In: Pylypenko SV, redaktor. Biolohichni, medychni ta naukovo-pedahohichni aspekty zdorovia liudyny [Biological, medical and scientific-pedagogical aspects of human health]: materialy mizhnar. nauk.-prakt. konf. Poltava: Astraia, 2020. p. 23-5. [in Ukrainian].
- Molokanova LV, Kvasnikova AA. Kolioroutvorennia kovbasnykh vyrobiv: problemy i mozhlyvi shliakhy vyrishennia. In: Obladnannia ta tekhnolohii kharchovykh vyrobnytstv [Equipment and technologies of food production] : zb. nauk. prats DonNUET. Donetsk: VTs DonNUET; 2010. p. 183-90. [in Ukrainian].
- Alan Davidson. Tom Jaine (ed.). The Oxford Companion to Food (3rd ed.). Oxford University Press 2014. 921 p.
- Bera TK, Kar SK, Yadav PK, Mukherjee P, Yadav S, Joshi B. Effects of monosodium glutamate on human health: A systematic review. World Journal of Pharmaceutical Sciences, 2017; 5(5):139-144. Available from: https://www.wjpsonline.org/admin/uploads/m9d27N.pdf.
- FAO/WHO Food Standards [Internet]. Сodex Аlimentarius: GSFA Online [updated up to the 42nd Session of the Codex Alimentarius Commission (2019); cited 2020 Nov 24]. Available from: http://www.fao.org/gsfaonline/index.html.
- Food Standards Agency [Internet]. Approved additives and E numbers; and related content [updated 10 Sept 2020; cited 2020 Nov 24]. Available from: https://www.food.gov.uk/businessguidance/approved-additives-and-e-numbers.
- Frank R. Greer, Michael Shannon. Infant Methemoglobinemia: The Role of Dietary Nitrate in Food and Water. Pediatrics, September 2005, Vol. 116, Issue 3, рр.784-786. DOI: https://doi.org/10.1542/peds.2005-1497.
- Kramer NI, Hoffmans Y, Wu S, Thiel A, Thatcher N, Allen TEH et al. Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs. Arch. Toxicol. 2019. doi: 10.1007/s00204-019- 02501-x.
- Kris Gunnars. Are Nitrates and Nitrites in Foods Harmful? Healthline [updated Febr 10, 2020; cited 2020 Nov 24]. Available from: https://www.healthline.com/nutrition/are-nitrates-and-nitritesharmful.
- Kris Gunnars. Are Nitrates and Nitrites in Foods Harmful? Healthline [updated Febr 10, 2020; cited 2020 Nov 24]. Available from: https://www.healthline.com/nutrition/are-nitrates-and-nitrites-harmful.
- Lemoine A, Pauliat-Desbordes S, Challier P, Tounian P. Adverse reactions to food additives in children: A retrospective study and a prospective survey. Arch Pediatr. 2020;27(7):368-71.
- Levorato S, Traussnig H, Schulte S, Boobis A, Rietjens I, Vinken M. Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs. Arch. Toxicol. 2019. doi: 10.1007/s00204-019- 02501-x.
- Lis K, Bartuzi Z. Natural food color additives and allergies. Alergia Astma Immunol. 2020;25(2):95-103.
- Masuda T, Shimazawa M, Hara H. Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone). Oxid Med Cell Longev. 2017;2017:9208489.
- Nandanwadkar SM, Mastiholimath V. A novel USP-HPTLC protocol compliant method for the simultaneous quantification of E-102, E-124, and E-133 azo dyes in consumer goods. J Planar Chromatogr Mod TLC. 2020;33(4):405-12.
- Shanmugasundaram P, Bavenro, Rujaswini T. A review on food coloring agents – safe or unsafe? Res J Pharm Technol. 2019;12(5):2503-5.
- U.S. Food and Drug Administration (FDA). An official website of the United States government [Internet]. Food: Food Ingredients & Packaging [updated 2020 Jul 30; cited 2020 Nov 24]. Available from: https://www.fda.gov/food/food-ingredients-packaging
- Valluzzi RL, Fierro V, Arasi S, et al. Allergy to food additives. Curr Opin Allergy Clin Immunol. 2019;19(3):256-62.
- Vsemirnaya organizaciya zdravoohraneniya [Internet]. Pishchevye dobavki [obnovleno 31 YAnv 2018; citiruetsya 24 Noya 2020]. Dostupno: https://www.who.int/ru/news-room/fact-sheets/detail/food-additives.
- Wexler P, Editor. Encyclopedia of Toxicology. Reference Work. Third Edition. Academic Press; 2014. 5220 p.
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Publication of the article |
«World of Medicine and Biology» №4(90), 2024 year, 260-264 pages, index UDK 617.7:613.29-071 |
DOI |
10.26724/2079-8334-2024-4-90-260-264 |