| About the author: |
S. V. Fedorov, D. T. Orishchak, T. I. Makovetska, B. L. Henyk, M. V. Bielinskyi, A. S. Herashchenko |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Patients with coronary artery disease and concomitant periodontitis exhibit more pronounced endothelial dysfunction compared to those with coronary artery disease alone. This prospective cohort study included 58 patients: 25 with coronary artery disease and 33 with coronary artery disease + periodontitis, conducted at Ivano–Frankivsk National Medical University from December 2023 to September 2024. In the coronary artery disease + periodontitis group, significantly higher levels of MMP–9 (126.76 [114.19; 146.21] ng/mL vs. 100.47 [81.22; 114.38] ng/mL, p<0.001) and TMAO (133.18 [111.27; 148.37] µmol/L vs. 91.80 [65.42; 109.53] µmol/L, p<0.001) were observed. Endothelial dysfunction was evidenced by lower flow-mediated dilation (9.92 [9.12; 12.24] % vs. 12.78 [10.52; 16.96] %, p=0.012), higher pulse-wave velocity (8.71 [7.93; 10.12] m/s vs. 6.53 [5.60; 8.90] m/s, p=0.011), and increased carotid intima-media thickness (0.76 [0.68; 0.81] mm vs. 0.62 [0.54; 0.73] mm, p=0.004). These results underscore the systemic impact of periodontitis on vascular health in coronary artery disease patients and suggest a need for integrated management strategies. |
| Tags |
coronary artery disease,periodontitis,endothelial dysfunction,inflammation,cardiovascular risk |
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| Publication of the article |
«World of Medicine and Biology» №1(91), 2025 year, 122-126 pages, index UDK 616.311.2+616.314.17)–02:616.12–005.4]–073.48 |
| DOI |
10.26724/2079-8334-2025-1-91-122-126 |
