| About the author: |
S. A. Shnaider, M. F. Konovalov, N. A. Ivchenko, O. O. Yudina, Zh. O. Novikova, L. B. Tsevukh, K. V. Khodorchuk |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
This research is devoted to the modeling of chronic epileptic activity and dental caries with the aim of experimentally evaluating biochemical markers of bone tissues in rats. In the experiment, dental caries was reproduced by transferring the animals to Stephan’s cariesogenic diet, while epileptic activity was induced using the kindling and post-kindling models. The rats were divided into groups of six animals each. The results revealed a significant increase in acid phosphatase activity in the dental pulp of rats subjected to the cariesogenic diet and epileptic activity, indicative of tissue resorption processes in the teeth. The decrease in alkaline phosphatase activity signifies impaired mineralization processes in the hard dental tissues and suppression of odontoblast function. The combined influence of these factors exacerbated the pathological changes in the condition of the hard dental tissues, underscoring the need for specialized preventive measures in patients with epilepsy. |
| Tags |
epilepsy,biochemical markers,bone tissue,rats,experiment |
| Bibliography |
- Vastianov RS, Konovalov MF. Zmina mineralnoyi shchilnosti kistkovoyi tkanyny v dynamitsi rozvytku khronichnoyi epileptychnoyi aktyvnosti. Biomedical and biosocial anthropology. 2015;25:87–92. [in Ukrainian].
- Martyniuk VY, Znamenska TK, Shveikina VB. Patofiziolohichni mekhanizmy rozvytku epilepsiyi ta osoblyvosti epileptohenezu v nezrilomu mozku. Modern Pediatrics. Ukraine. 2021;2(114):26–39. DOI: 10.15574/SP.2021.114.26. [in Ukrainian].
- Nakaz Ukrayiny “Pro zatverdzhennya Poryadku provedennya naukovymy ustanovamy doslidiv, eksperymentiv na tvarynakh”. Ministerstvo osvity i nauky Ukrayiny. 2012;249. [in Ukrainian].
- Rohach IM, Keretsman AO, Sitkar AD. Pravylno vybranyy metod statystychnoho analizu – shlyakh do yakisnoyi interpretatsiyi danykh medychnykh doslidzhen. Naukovyy visnyk Uzhhorodskoho universytetu, seriya “Medytsyna”. 2017;2(56):124–128. [in Ukrainian].
- Shnaider SA, Levytskyi AP. Eksperymentalna stomatolohiya. Ch. I: Eksperymentalni modeli stomatolohichnykh zakhvoryuvan. Odesa: KP «Odeska miska drukarnya». 2017:167. [in Ukrainian].
- Ali A. Global Health: Epilepsy. Semin Neurol. 2018;38(2):191–199. DOI: 10.1055/s-0038-1646947.
- Kharchenko АV, Yelinska AM, Shepitko VI, Stetsuk EV. Chronic periodontitis in patients with chronic duodenal ulcer. World of Medicine and Biology. 2022;79(1):232–236. DOI: 10.26724/2079-8334-2022-1-79-232-236.
- Oak A. Epilepsy and Oral Health Care. Natl J Integr Res Med. 2018;9(3):71–74.
- Shandra AA, Mazarati AM, Godlevsky LS, Vastyanov RS. Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models. Epilepsia. 1996;37(3):269–74. DOI: 10.1111/j.1528-1157.1996.tb00024.x.
- Shata MO, Shatla HM, Badawy S., Metkees MM. Effects of Levetiracetam and Topiramate Monotherapy on Oral Health in Epileptic Children. The Egyptian Journal of Hospital Medicine. 2021;84(1):2411–2416. DOI: 10.21608/ejhm.2021.184657.
- Wood JC, Jackson JS, Jakubs K, Chapman KZ, Ekdahl CT, Kokaia Z, et al. Functional integration of new hippocampal neurons following insults to the adult brain is determined by characteristics of pathological environment. Exp Neurol. 2011;229(2):484–93. DOI: 10.1016/j.expneurol.2011.03.019.
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| Publication of the article |
«World of Medicine and Biology» №1(91), 2025 year, 203-206 pages, index UDK 57.084.1:[599.323.45+616.314-002+616.853] |
| DOI |
10.26724/2079-8334-2025-1-91-203-206 |
