РусскийEnglishУкраїнська
  • Главная
  • Полезные ссылки
  • О журнале
  • Авторам
  • Редакционная коллегия

  • Статья
    Подпалова О.М., Нурищенко Н.Е.

    МЕХАНИЗМЫ РАЗВИТИЯ АЛКОГОЛЬНОЙ МІОПАТИИ СКЕЛЕТНЫХ МЫШЦ


    Об авторе: Подпалова О.М., Нурищенко Н.Е.
    Рубрика ОБЗОРЫ ЛИТЕРАТУРЫ
    Тип статьи Обзорная статья
    Аннотация Алкогольная миопатия считается многофакторной болезнью. Механизмы, ведущие к развитию патологии мышц при чрезмерном потреблении алкоголя, имеют несколько вариантов реализации. Так алкогольная миопатия сопровождается изменением окислительно-восстановительного статуса и антиоксидантным дисбалансом в скелетных мышцах. Хронический прием алкоголя и острая алкогольная интоксикация способны снижать скорость белкового синтеза, в том числе и миофибриллярных белков. Злоупотребление алкоголем ведет к повреждению сигнальных каскадов, а также повышение уровня апоптоза в скелетных мышцах.
    Ключевые слова этанол, алкоголь, миопатия, белковий синтез, интерлейкин, окисление свободными радикалами
    Список цитируемой литературы
    • Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart and skeletal muscles: protective effects of anti-oxidants. / Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. J // Pharmacol Exp Ther. - 2007. - V. 298. - P. 737–743
    • Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes. / Hong-Brown LQ, Brown CR, Huber DS, Lang CH // Alcohol Clin Exp Res. - 2006. - V. 30. - P. 1297–1307
    • Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. / Lang CH, Frost RA, DeshpandeN, Kumar V, Vary TC, Jefferson LS, Kimball SR // Am J Physiol Endocrinol Metab. - 2003. - V. 285. - P. E1205–E1215
    • Alcohol increases tumor necrosis alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice / Robin MA, Demeilliers C, Sutton A, Apradis V, Maisonneuve C, Dubois S, Poirel O, Letteron P, Pessayre D, Fromenty B. // Hepatology. – 2005. – V. 42. – P. 1280–1290.
    • Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism. / Lang CH, Pruznak AM, Deshpande N, Palopoli MM, Frost RA, Vary TC // Alcohol Clin Exp Res. - 2004. - V. 28. - P. 1758–1767
    • Alcoholic muscle disease and biomembrane perturbations. / Adachi J, Asaano M, Ueno Y, Niemela O, Ohlendieck K, Peters TJ, Preedy VR //  J Nutr Biochem. - 2003. - V. 14. - P. 616–625
    • Alcoholic myopathy: lack of effect of zinc supplementation. / Duraґn-Castelloґn MC, Gonzaґlez-Reimers E, Loґpez-Lirola A, Martıґn-Olivera R, Santolaria-Fernaґndez F, Galindo Martıґn L, Abreu-Gonzaґ lez P, Gonza ґlez-Hernaґndez T // Food Chemical Toxicol. - 2005. - V. 43. - P. 1333–1343
    • Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. / Nieman DC, Davis JM, Henson DA, Walberg-Rankin J, Shute M, Dumke CL, Utter AC, Vinci DM, Carson JA, Brown A, Lee WJ, McAnulty SR, McAnulty LS. // Appl Physiol. - 2003. - V. 94. - P. 1917–1925
    • Chronic alpha-tocopherol supplementation in rats does not ameliorate either chronic or acute alcohol-induced changes in muscle protein metabolism. / Koll M, Beeso JA, Kelly FJ, Simanowski UA, Seitz HK, Petes TJ, Preedy VR //  Clin Sci (Lond). - 2003. - V. 104. - P. 287–294
    • Evidence of apoptosis in alcoholic cardiomyopathy. / Fernaґndez-Sola` J, Fatjoґ F, Sacanella E, Estruch R, Bosch X, Urbano-Maґ rquez A, Nicolas JM // Hum Pathol. - 2006. - V. 37. - P. 1100–1110
    • Expression of muscle uncoupling protein 3 mRNA in response to ethanol dosage. / Baffy G, Seitz H, Koll M, Preedy VR // Alcohol Clin Exp Res. - 2006. - V. 30(Suppl). - P. 147
    • Glutathione metabolism and its implications for health. /  Wu G, Fang YZ, Yang S et al.// The Journal of nutrition.  – 2004. – V.134. - P. 489-92
    • Hepatotoxicity of iron overload: mechanisms of ion-induced hepatic fibrogenesis / Ramm GA, Ruddell RG // Semin Liver Dis. – 2005. – V. 25. – P. 433–439.
    • Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA. / Hofer T, Badouard C, Bajak E, Ravanat JL, Mattsson A, Cotgreave IA // Biol Chem. - 2005. - V. 386. - P. 333–337
    • Inhibition of store-operated Ca(2+) channels prevent ethanol-induced intracellular Ca(2+) increase and cell injury in a human hepatoma cell line. / Liu H, Jia X, Luo Z, Guan H, Jiang H, Li X, Yan M. // Toxicol Lett. - 2012. - V. Feb 208(3). - P. 254-61
    • IL-6 increases insulin stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMPK. / Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G, Prelovsek O, Hohnen-Behrens C, Watt MJ, James DE, Kemp BE, Pedersen BK, Febbraio MA. // Diabetes. - 2006. - V. 55. - P. 2688–2697
    • Interleukin-15 and other myokines in chronic alcoholics. / González-Reimers E, Fernández-Rodríguez CM, Santolaria-Fernández F, de la Vega-Prieto MJ, Martín-González C, Gómez-Rodríguez MÁ, Alemán-Valls MR, Rodríguez-Gaspar M // Alcohol  Epub. - 2011. - V. Jun 2.Sep-Oct; 46(5). - P. 529-33
    • Mechanisms of alcohol-induced tissue injury. / Molina PE, Hoek JB, Nelson S, Guidot D, David M, Lang Ch, Wands JR, Crawford JD // Alcohol Clin Exp Dis. - 2003. - V. 27. - P. 563–575
    • Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. / Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N Free // Radic Biol Med. - 2004. - V. 37. - P. 755 - 767
    • Molecular and cellular events in alcohol-induced muscle disease / Fernandez-Sola J, Preedy VR, Lang CH et al. // Alcohol Clin Exp Res. - 2007. - V. 31. - P. 1953–62
    • Muscle as an endocrine organ: focus on muscle-derived interleukin-6 / Pedersen BK, Febbraio MA // Physiological reviews. - 2008. – V. 88 (4). – P.  1379–406.
    • Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats / Otis JS, Guidot DM // Alcohol Clin Exp Res. – 2009. – V. 33. – P. 1450–9.
    • Protein and mRNA levels of the myosin heavy chain isoforms I[beta], IIa, IIx and IIb in Type I and Type II fibre-predominant rat  skeletal muscles in response to chronic alcohol feeding / Reilly ME, McKoy G, Mantle D, Peters TJ, Goldspink G, Preedy VR. // Muscle Res Cell Motil. – 2000. – V. 21. – P. 763–773.
    • Rapid rates of newly synthesized mitochondrial protein degradation are significantly affected by the generation of mitochondrial free radicals. / Basoah A, Matthews PM, Morten // KJ FEBS Lett. - 2005. - V. 579. - P. 6511–6517
    • Redox regulation of skeletal muscle. / Jackson MJ // IUBMB Life. - 2008. - V. 60. - P. 497–501
    • Relationship between ethanol-related diseases and nutritional status in chronically alcoholic men. / Estruch R, Nicolas JM, Villegas E, Junque A, Urbano-Marquez A // Alcohol Alcohol. - 1993. - V. 28. - P. 543–550
    • Restoration of protein synthesis in heart and skeletal muscle after withdrawal of alcohol / Vary TC, Nairn AC, Lang CH. // Alcohol Clin Exp Res. – 2004. – V.28. – P. 517–525.
    • Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditions. / Frost RA, Nystrom G, Burrows PV, Lang CH // Alcohol Clin Exp Res. - 2005. - V. 29. - P. 1247–1256
    • The effect of high fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice. / Hoeks J, Hesselink MK, Sluiter W, Schaart G, Willems J, Morrisson A, Clapham JC, Saris WH, Schrauwen P // FEBS Lett. - 2006. - V. 580. - P. 1371–1375
    • The effects of alcohol on skeletal and cardiac muscle / Urbano-Maґrquez A, Fernaґndez-Sola` J. // Muscle Nerve. – 2004. – V. 30. – P. 689–707.
    Публикация статьи «Мир Медицины и Биологии» №3(34), 2012 год, 159-163 страницы, код УДК 57.043:577