THE INVESTIGATION OF VASCULAR STIFFNESS IN PATIENTS DEPENDING ON DIFFERENT DEGREES OF ARTERIAL HYPERTENSION

Authors:

Abstract:

The purpose of the study was to investigate the dependence of vascular stiffness on blood pressure level in patients with arterial hypertension. 90 people were included into the clinical observation. These patients were randomized into 2 groups. The group 1 was consisted of 15 healthy individuals The group 2 was consisted of 75 patients with arterial hypertension of various degrees. Pulse wave velocity was measured in all patients. The correlation between pulse wave velocity vs age and systolic/diastolic blood pressure was calculated. The data obtained allowed to state that pulse wave velocity index has tight connection with blood pressure values. The authors reveal high statistical correlation between pulse wave velocity index and blood pressure values. The authors suppose that arterial stiffness might be the earlier diagnostic tool for to approaching vascular accident and, therefore, propose the pulse wave velocity index measurement in patients with initial signs of arterial hypertension.

Keywords:

vascular wall vascular elasticity stiffness arterial hypertension blood pressure pulse wave velocity index

References:

1. Baier D, Teren A, Wirkner K, Loeffler M, Scholz M. Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult. Clin Res Cardiol. 2018; 107(11): 1050–1061. doi: 10.1007/s00392-018-1278-3
2. Boutouyrie P, Chowienczyk P, Humphrey JD, Mitchell GF. Arterial Stiffness and Cardiovascular Risk in Hypertension. Circ Res. 2021; 128(7): 864–886. doi: 10.1161/CIRCRESAHA.121.318061
3. Forte M, Stanzione R, Cotugno M, Bianchi F, Marchitti S, Rubattu S. Vascular ageing in hypertension: Focus on mitochondria. Mech Ageing Dev. 2020; 189: 111267. doi: 10.1016/j.mad.2020.111267
4. Jia G, Aroor AR, Jia C, Sowers JR. Endothelial cell senescence in aging-related vascular dysfunction. Biochim Biophys Acta Mol Basis Dis. 2019;1865(7):1802–1809. doi: 10.1016/j.bbadis.2018.08.008
5. Johansson M, Fedorowski A, Jordan J, Engström G, Nilsson PM, Hamrefors V. Orthostatic blood pressure adaptations, aortic stiffness, and central hemodynamics in the general population: insights from the Malmö Offspring Study (MOS). Clin Auton Res. 2023; 33(1): 29–40. doi: 10.1007/s10286-022-00911-z
6. Laurent S, Boutouyrie P, Cunha PG, Lacolley P, Nilsson PM. Concept of extremes in vascular aging. From early vascular aging to supernormal vascular aging. Hypertension. 2019;74(2):218–228
7. Laurent S, Boutouyrie P. Arterial Stiffness and Hypertension in the Elderly. Front Cardiovasc Med. 2020; 7: 544302. doi: 10.3389/fcvm.2020.544302
8. Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM. et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update from the GBD 2019 Study. J Am Coll Cardiol. 2020; 76(25): 2982-3021 doi: 10.1016/j.jacc.2020.11.010
9. Rusu CC, Kacso I, Moldovan D, Potra A, Tirinescu D, Ticala M. Et al. Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients. Diagnostics (Basel). 2023; 13(14) :2462. Doi: 10.3390/diagnostics13142462
10. Tian X, Zuo Y, Chen S, Zhang Y, Zhang X, Xu Q, et al. Hypertension, arterial stiffness, and diabetes: a prospective cohort study. Hypertension. 2022;79(7):1487–1496. Doi: 10.1161/hypertensionaha.122.19256
11. Yue X, Chen L, Shi Y, Suo Y, Liao S, Cheang I. Et al. Comparison of arterial stiffness indices measured by pulse wave velocity and pulse wave analysis for predicting cardiovascular and all-cause mortality in a Chinese population. Hypertens Res. 2024; 47(3): 767–777. Doi: 10.1038/s41440-023-01552-z
12. Zdravkovic M, Popadic V, Klasnja S, Klasnja A, Ivankovic T, Lasica R. et al. Coronary Microvascular Dysfunction and Hypertension: A Bond More Important than We Think. Medicina (Kaunas). 2023; 59(12): 2149. Doi: 10.3390/medicina59122149
13. Zhdan VМ, Kitura YeM, Babanina Мyu, Kitura Оye, Tkachenko MV, Kyrian OA, Ivanytskyi IV. Medical rehabilitation of patients with arterial hypertension in general medical practice. Visnyk problem biolohiyi I medytsyny. 2022; 4(167): 59–65. Doi: 10.29254/2077-4214-2022-4-167-59-65
14. Zolotaryova NA, Vastyanov RS, Gunenko II. Portable device use for arterial stiffness determination as a control method at the recovery stage of rehabilitation. Acta Balneologica. 2022; 64(6): 557–560. DOI: 10.36740/ABAL202206112
15. Zolotaryova NA, Vastyanov RS, Gunenko II, Herasimenko OS. Influence of sex, age and degree of arterial hypertension on the vascular wall stiffness. World of Medicine and Biology. 2022; 4(82): 63–68. DOI: 10.26724/2079-8334-2022-4-82-63-68

Publication:

«World of Medicine and Biology» Vol. 20 No. 87 (2024) , с. 65-69
УДК 616.12-008.331-06:616.12/.13]-05

DOI:

https://doi.org/10.26724/2079-8334-2024-1-87-65-69