RESULTS OF A DENSITOMETRIC STUDY IN WOMEN WITH EARLY MENOPAUSE AND PREMATURE OVARIAN FAILURE

Authors:

Abstract:

The study included 50 women divided into two groups: early menopause (n=19) and premature ovarian insufficiency (n=31). A control group consisted of 20 women with preserved menstrual function. Serum estradiol, vitamin D, and ionized calcium were measured, and quantitative ultrasound densitometry was performed (SOS, BUA, BQI, T- and Z-scores). Correlation analysis was used to assess relationships between hormonal, metabolic, and densitometric parameters. Women with premature ovarian insufficiency demonstrated more pronounced bone mineral density reduction compared to those with early menopause. Estradiol levels showed a weak negative correlation with densitometric indices, whereas ionized calcium was positively correlated with BQI and T-score. Hypoestrogenism is a key factor in the reduction of bone mineral density in women with early menopause and premature ovarian insufficiency. A comprehensive assessment of hormonal and metabolic status, combined with densitometry, is essential for the early detection of osteopenia and the prevention of osteoporosis.

Keywords:

early menopause premature ovarian insufficiency estradiol vitamin D calcium ultrasound densitometry bone mineral density

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Publication:

«World of Medicine and Biology» Vol. 22 No. 1 (2026) , с. 28-32
УДК 618.11-008.64; 616.728.3-007.17-073.7:618.173

DOI:

https://doi.org/10.26724/2079-8334-2026-1-95-28-32