REACTIVE CHANGES IN THE VESSELS OF THE HEMOMICROCIRCULATORY BED IN THE RETINA OF RATS UNDER THE INFLUENCE OF A COMPLEX OF FOOD ADDITIVES

Authors:

Abstract:

The paper examines the effect of a complex of food additives on the vessels of the hemomicrocirculatory bed of the rat retina. Ponceau 4R can induce oxidative stress and inflammation in the retina, potentially leading to damage to retinal pigment epithelial cells. This can potentially cause vision loss and other eye problems. The effect of the complex of nutritional supplements on the resistive link of the hemomicrocirculatory bed is manifested by spasm due to activation of NMDA receptors at week 1, partial compensation due to angiogenesis at week 4, and remodeling of fibrous tissue and loss of elasticity at week 12–16. Regarding the capacitive link, spasm is determined in the early stages, while dilation occurs in the later stages. In the exchange link, ischemic spasm was detected in the early stages of the experiment, endothelial desquamation occurred in the eighth week, and pericyte loss and microaneurysm formation were observed in the 12th to 16th week.

Keywords:

retina rats monosodium glutamate sodium nitrite Ponceau 4R oxidative stress

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Publication:

«World of Medicine and Biology» Vol. 21 No. 93 (2025) , с. 196-199
УДК 617.735:616.1:614.31:599.323.4

DOI:

https://doi.org/10.26724/2079-8334-2025-3-93-196-199