EXPERIMENTAL EVALUATION OF A THERAPEUTIC-PROPHYLACTIC COMPLEX ON BIOCHEMICAL MARKERS IN RAT GINGIVAL HOMOGENATES UNDER MODELLED FLUOROSIS AND ORTHODONTIC INTERVENTION

Authors:

Abstract:

The study was devoted to evaluate the effect of a therapeutic-prophylactic complex on inflammatory and oxidative-stress biomarkers in gingival homogenates of rats exposed to chronic excessive fluoride intake and orthodontic tooth movement. Experimental studies were carried out on 40 male Wistar rats (herd breeding), 4 months of age, with an average body mass of 280±14 g. Summarising the biochemical findings, orthodontic ligature fixation superimposed on fluorosis markedly disrupted the antioxidant-prooxidant balance and intensified inflammatory processes in the gingival tissues. Administration of the therapeutic-prophylactic complex under conditions of experimental fluorosis and orthodontic intervention improved antioxidant status, decreased lipid peroxidation, and attenuated inflammation, thereby confirming the antioxidant and anti-inflammatory properties of the agents incorporated into the developed therapeutic-prophylactic complex.

Keywords:

fluoride fluorosis gingiva rats experimental study

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Publication:

«World of Medicine and Biology» Vol. 21 No. 93 (2025) , с. 199-203
УДК [57.084.1+546.16]:616.31-08-039.71

DOI:

https://doi.org/10.26724/2079-8334-2025-3-93-199-203