ENDOTHELIAL DYSFUNCTION PATHOGENETIC SIGNIFICANCE AND ITS MARKERS PROGNOSTIC IMPORTANCE IN SPONTANEOUS ARTERIAL HYPERTENSION

Authors:

Abstract:

The purpose of the study was to investigate the diagnostic importance of main endothelial dysfunction biomarkers in experimental arterial hypertension with an inflammatory component in its pathogenesis. Blood levels of von Willebrand factor, plasminogen activator inhibitor 1, endothelin 1, and soluble vascular cell adhesion molecule 1 occurred to be significantly increased in rats with spontaneous arterial hypertension. The endothelial dysfunction markers selected for this study are the substances that evidently highlight its specific pathogenetic mechanisms and consequently the mechanisms of arterial hypertension development. The data obtained highlighted endothelial dysfunction complex mutually reinforcing pathogenetic mechanisms were detected, which showed its pathogenesis complexity and multi-component nature and reflected the diverse body systems pathological dysfunction systemic nature. The authors concluded that adequate and effective therapy for arterial hypertension should consider the identified pathogenetic mechanisms and be aimed at endothelial dysfunction development prevention and progression.

Keywords:

endothelial dysfunction arterial hypertension von Willebrand factor plasminogen activator inhibitor-1 soluble vascular cell adhesion molecule-1 endothelin-1 pathogenesis

References:

1. Christopoulos G, Christopoulou V, Stamatiou K, Babionitakis A, Routsias JG. Assciation Between Soluble Cell Adhesion Molecules (sP-Selectin, sE-Selectin, and sICAM-1) and Antibodies Against the Antigens of Proteus mirabilis in Rheumatoid Arthritis Patients. Cureus. 2024; 16(7): 64942. doi: 10.7759/cureus.64942.
2. Drożdż D, Drożdż M, Wójcik M. Endothelial dysfunction as a factor leading to arterial hypertension. Pediatric nephrology (Berlin, Germany). 2023; 38(9): 2973–2985.
3. England BR, Thiele GM, Anderson DR, Mikuls TR. Increased cardiovascular risk in rheumatoid arthritis: Mechanisms and implications. BMJ; 2018: 361: k1036. doi: 10.1136/bmj.k1036.
4. Jung RG, Simard T, Di Santo P, Labinaz A, Moreland R, Duchez A-C. et al. Performance of plasminogen activator inhibitor-1 as a biomarker in patients undergoing coronary angiography: Analytical and biological considerations. Diab Vasc Dis Res. 2019; 16(5): 478–482. doi: 10.1177/1479164119845123.
5. Manz XD, Bogaard HJ, Aman J. Regulation of VWF (Von Willebrand Factor) in Inflammatory Thrombosis. Arteriosclerosis, thrombosis, and vascular biology. 2022; 42(11): 1307–1320. doi: 10.1161/ATVBAHA.122.318179.
6. Moroz VM, Shandra OA, Vastyanov RS, Yoltukhivsky MV, Omelchenko OD. Physiology. Vinnytsia : Nova Knyha, 2016: 722.
7. Nagy TL, Mikecs B, Lohinai ZM, Vág J. Dose-related effect of acetylcholine on human gingival blood flow. BMC Oral Health. 2024; 24(1): 1398. doi: 10.1186/s12903-024-05169-7.
8. Steyers CM 3rd, Miller FJ Jr. Endothelial dysfunction in chronic inflammatory diseases. Int. J. Mol. Sci. 2014, 15,
9. –11349. doi: 10.3390/ijms150711324.
10. Szeremeta A, Jura-Półtorak A, Zoń-Giebel A, Olczyk K, Komosińska-Vassev K. TNF-α Inhibitors in Combination with MTX Reduce Circulating Levels of Heparan Sulfate/Heparin and Endothelial Dysfunction Biomarkers (sVCAM-1, MCP-1, MMP-9 and ADMA) in Women with Rheumatoid Arthritis. J. Clin. Med. 2022; 11(14): 4213. doi: 10.3390/jcm11144213.
11. Vanhoutte PM, Shimokawa H, Feletou M, Tang EH. Endothelial dysfunction and vascular disease – a 30th anniversary update. Acta Physiol (Oxf). 2017; 219(1): 22–96. doi: 10.1111/apha.12646.
12. Zhang J. Biomarkers of endothelial activation and dysfunction in cardiovascular diseases. Reviews in cardiovascular medicine. 2022; 23(2): 73. doi: 10.31083/j.rcm2302073.
13. Zhang G, Lin X, Shao Y, Su C, Tao J, Liu X. Berberine reduces endothelial injury and arterial stiffness in spontaneously hypertensive rats. Clin Exp Hypertens. 2020; 42(3): 257–265. doi: 10.1080/10641963.2019.1632339.
14. Zhu Y, Xian X, Wang Z, Bi Y, Chen Q, Han X. et al. Research progress on the relationship between atherosclerosis and inflammation. Biomolecules. 2018; 8: 80. doi: 10.3390/biom8030080.
15. Zolotaryova NA, Vastyanov RS. The investigation of vascular stiffness in patients depending on different degrees of arterial hypertension. World of Medicine and Biology. 2024; 1(87): 65–69. doi: 10.26724/2079-8334-2024-1-87-65-69.
16. Zolotaryova NA, Vastyanov RS, Gunenko II, Herasimenko OS. Influence of sex, age and degree of arterial hypertension on the vascular wall stiffness. World of Medicine and Biology. 2022; 4(82): 63–68. doi: 10.26724/2079-8334-2022-4-82-63-68.

Publication:

«World of Medicine and Biology» Vol. 20 No. 90 (2024) , с. 203-207
УДК 616.12-008.331.1-005.4-06:616.379

DOI:

https://doi.org/10.26724/2079-8334-2024-4-90-203-207