NOVEL BIOMARKERS: THE RENIN-ALDOSTERONE AND ENKEPHALINERGIC SYSTEMS IN DIAGNOSTIC OF KIDNEY CANCER, KIDNEY STONE AND NEPHROPATHY OF RHEUMATOID ARTHRITIS GENESIS

Authors:

Abstract:

The renin-angiotensin system and endogenous opioids are important bioactive neuropeptides, which are widely distributed in the brain and peripheral regions to produce diverse biological and neurobiological activities. Research evidence demonstrates significant positive as well as negative interactions between the renin-angiotensin system and endogenous opioids. The purpose of the study was to investigate the association between the renin-aldosterone and enkephalinergic systems in patients with kidney cancer, kidney stone and nephropathy of rheumatoid arthritis genesis. Survival and decline in eGFR ≤ 40 % analysis was performed using the Kaplan–Meier method; univariate and multivariate analyses were undertaken using log rank test and Cox’s regression model, respectively. Met-enkephalin has a high prognostic efficacy for assessing the development of end-stage kidney disease in patients with nephrolithiasis. Level activity renin plasma was an independent predictor of decline in glomerular filtration rate in patients with ureteral stones, patients with nephropathy on the background of rheumatoid arthritis and cancer-specific mortality in .patients with renal cell cancer.

Keywords:

renin-aldosterone system methionine-enkephalin kidney disease

References:

1. Pokhylko VІ, Kovalova OM, Chernyavska YuІ, Tsvіrenko SM, Sarychev VP. Vplyv polіmorfіzmu genіv renіn-angeotenzyvnoyi systemy na perebіg rannіkh bakterіalnykh іnfektsіy u peredchasno narodzhenykh dіtey. Aktualnі problemy suchasnoyi medytsyny: Vіsnyk Ukrayinskoyi medychnoyi stomatologіchnoyi akademіyi. 2019; 19, 4 (68): 19–24. [in Ukrainian]
2. Sharashova EE, Kholmatova KK, Gorbatova MA, Grjibovski AM. Cox regression in health sciences using SPSS software. Nauka i Zdravookhranenie [Science & Healthcare]. 2017; (6): 5–27. [in Russian]
3. Bali A, Randhawa PK, Jaggi AS. Interplay between RAS and opioids: Opening the Pandora of complexities. Neuropeptides. 2014;48(4):249–256. doi:10.1016/j.npep.2014.05.002
4. Bayomy O, Zaheer S, Williams JS, Curhan G, Vaidya A. Disentangling the relationships between the renin-angiotensin-aldosterone system, calcium physiology, and risk for kidney stones. J Clin Endocrinol Metab. 2020;105(6):1937––1946. doi:10.1210/clinem/dgaa123
5. Brown P, Stallwood J, Costa M, Bruneval P. Renin-producing Tumour in the Kidney of a Cat. J Comp Pathol. 2019;170:70–73. doi:10.1016/j.jcpa.2019.05.009
6. Chen WG, Zhou TT, Zhou P, Li XW, Wu Z, Zhang KY, et al. Aldosterone-to-renin ratio acts as the predictor distinguishing the primary aldosteronism from chronic kidney disease. Int J Clin Exp Pathol. 2015;8(6):6901–6909.
7. Garige M, Poncet S, Norris A, Chou CK, Wu WW, Shen RF, et al. Extended Opioid Exposure Modulates the Molecular Metabolism of Clear Cell Renal Cell Carcinoma. Life. 2023;13(5). doi:10.3390/life13051196
8. Kobiec T, Otero-Losada M, Chevalier G, Lucas Udovin L, Bordet S, Menéndez-Maissonave C, et al. The Renin-Angiotensin System Modulates Dopaminergic Neurotransmission: A New Player on the Scene. Front Synaptic Neurosci. 2021; 13: 638519. doi: 10.3389/fnsyn.2021.638519
9. Lei L, Liang H, Qu Y, Ji N. Association between triglyceride-glucose index and worsening renal function in the elderly. Front Nutr. 2022;9. doi:10.3389/fnut.2022.951564
10. Nwia SM, Leite APO, Li XC, Zhuo JL. Sex differences in the renin-angiotensin-aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases. Front Cardiovasc Med. 2023;10. doi:10.3389/fcvm.2023.1198090
11. Park SY, Park JE, Kim H, Park SH. Review of statistical methods for evaluating the performance of survival or other time-to-event prediction models (From conventional to deep learning approaches). Korean J Radiol. 2021;22. doi:10.3348/kjr.2021.0223.
12. RajkumarV, WaseemM. Hypoaldosteronism. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
13. Rysztak LG, Emily M. Jutkiewicz EM. The role of enkephalinergic systems in substance use disorders. Front Syst Neurosci. 2022; 16: 932546. doi: 10.3389/fnsys.2022.932546
14. Suh SH,Jung JH,Oh TR,Yang EM,Choi HS,Kim CS,et al. Rheumatoid arthritis and the risk of end-stage renal disease: A nationwide, population-based study. Front Med (Lausanne). 2023; 10: 1116489. doi: 10.3389/fmed.2023.1116489
15. Zagon IS, McLaughlin PJ. Opioid growth factor and the treatment of human pancreatic cancer: A review. World J Gastroenterol. 2014;20(9):2218–2223. doi:10.3748/wjg.v20.i9.2218.

Publication:

«World of Medicine and Biology» Vol. 19 No. 85 (2023) , с. 101-107
УДК 616.61-006:616.65+576.367

DOI:

https://doi.org/10.26724/2079-8334-2023-3-85-101-107