EFFECT OF LONG-TERM USE OF PROTON PUMP INHIBITORS ON THE CONTENT OF NITRITE IONS IN THE BLOOD SERUM AND MUCOUS COATING OF THE GASTROINTESTINAL TRACT OF RATS

Authors:

Abstract:

The purpose of the study was to determine the content of nitrite ions in blood serum and mucous membranes of the stomach and colon in rats under the conditions of long-term use of proton pump inhibitors Omeprazole and Pantoprazole. The study was performed on 30 white non-linear male rats, divided into three groups. The control (first group) received water for injections intraperitoneally once a day for 28 days. The second – Omeprazole. The third – Pantoprazole. After long-term administration of omeprazole and pantoprazole, the concentration of NO2- in blood serum increased by 24 % (p<0.05) and 13 % compared to the control group. The increase in the concentration of NO2- in the mucous membranes of the stomach and colon after 28-day suppression of HCl secretion in the stomach by Omeprazole and Pantoprazole was much more pronounced and amounted in the stomach to 144 % (p<0.05) and 85 % (p<0.05) more compared to the control group. In the mucous membrane of the large intestine, it was 159 % (p<0.05) and 119 % more than in the control group. Long-term inhibition of hydrochloric acid secretion in the stomach of rats by proton pump blockers Omeprazole and Pantoprazole caused excessive generation of nitric oxide in blood serum and mucous membranes of the digestive tract of rats. The negative effect of pantoprazole was less pronounced than that of omeprazole.

Keywords:

hypochlorhydria pantoprazole omeprazole inflammatory process

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Publication:

«World of Medicine and Biology» Vol. 19 No. 85 (2023) , с. 205-208
УДК 615.24:[591.111.1+591.433/434]:599.323.4

DOI:

https://doi.org/10.26724/2079-8334-2023-3-85-205-208