PRIMARY AND SECONDARY PREVENTION OF CARDIOVASCULAR PATHOLOGY IN INJURED WITH COMBAT TRAUMA

Authors:

Abstract:

The purpose of the study was to develop and implement measures for primary and secondary prevention of cardiovascular pathology in injured with combat trauma. The data of 448 injured with combat trauma who were admitted to the National Military Medical Clinical Center «Main Military Clinical Hospital» were analyzed. Analysis of the average values of biochemical blood parameters showed the presence among injured with combat trauma and signs of cardiovascular disease more pronounced metabolic disorders, cytolysis and inflammation compared with injured without such complication: high levels of fibrinogen (by 11.1 %, p=0.0294), glucose (by 11.1 %, p=0.0004), asparagine transaminase (by 74.6 %, p=0.0005), alanine transaminase (by 58.4 %, p=0.0013), and lower levels of total protein (by 7.1 %, p=0.0008). The obtained results allowed us to offer hypermetabolism syndrome as one of the mechanisms of cardiovascular pathology development in injured with combat trauma, as well as to develop and implement approaches for prevention of this syndrome associated with the secondary pathology of the cardiovascular system.

Keywords:

metabolism psychological support military medicine cardiology

References:

1. Boyarintsev VV, Yevseyev MA. Metabolizm i nutritivnaya podderzhka khirurgicheskogo patsiyenta: Rukovodstvo dlya vrachey. SPb.: Onli-Press. 2017; 260 s. ISBN 978-5-906042-10-1. [in Russian]
2. Baraz VR, Pegashkin VF. Ispolzovanie MS Excel dlya analiza statisticheskikh dannykh. Nizhniy Tagil: Nizhnetagilskiy tehnologicheskiy institut (filial) Uralskogo federalnogo universiteta; 2014; 181 s.[in Russian]
3. Bolukh VA. Suchasni matematychni modeli v termodynamitsi biolohichnykh protsesiv. Medytsyna osvita. 2018; 4 :127-131. doi: 10.11603/me.2414–5998.2018.4.9007. [in Ukrainian]
4. Enikeev DA, Hisamov JeN, Pavlov VN, Nurgaleeva EA, Farshatova ER, Srubilin DV, et al. Vvedenie v klinicheskuju patofiziologiju. Tipovye patologicheskie processy: uchebnoe posobie. Ufa: Izd-vo FGBOU VO BGMU Minzdrava Rossii; 2017; 164 s. [in Russian]
5. Zvonarev SV. Osnovy matematicheskogo modelirovaniya: uchebnoe posobie. Ekaterinburg: Izdatelstvo Uralskogo universiteta; 2019. 112 s. [in Russian]
6. Petri A, Sebin K. Naglyadnaya meditsinskaya statistika: uchebnoye posobiye.; Leonov VP, redactor. Moskva: GEOTAR-Media; 2019; 216 s. [in Russian]
7. Sydorova NM, Halushka AM, Voronko AA, Kazmirchuk AP, Tretyak DD, Spaska HO, et al. Suchasni voyenni konflikty ta vtorynna patolohiya sertsevo-sudynnoyi systemy: statystyka, mozhlyvosti prohnozuvannya ta poperedzhennya. Suchasni aspekty viyskovoyi medytsyny. 2019; 26(2):70–79. doi: 10.32751/2310-4910-2019-26-29. [in Ukrainian]
8. Sydorova NM, Peshkova MI, Voronko AA, Khomenko IV, Tretiak DD. Rozrakhunok ryzyku rozvytku sertsevo-sudynnoi patolohii, shcho maie tryvalyi perebih, u postrazhdaloho z boiovoiu travmoiu: klinichnyi vypadok. World Science. 2020; 54 :35–42. Available at: doi:https://doi.org/10.31435/rsglobal_ws/28022020/6928. [in Ukrainian]
9. Kholod AH. Patolohichni zminy sertsevo-sudynnoi systemy u vazhkoporanenykh. Suchasni aspekty viiskovoyi medytsyny. 2015; 22(1) :166–168. [in Ukrainian]
10. Shevchuk VI, BeliaievaNM, Yavorovenko OB, Kurylenko IV, Haliutyna OIu. Sotsialni naslidky urazhennya vnutrishnikh orhaniv v uchasnykiv antyterorystychnoyi operatsii. Zbirnyk naukovykh prats spivrobitnykiv NMAPO imeni P.L. Shupyka. 2016; 25 :77–83. [in Ukrainian]
11. Edmondson D, von Känel R. Posttraumatic Stress Disorder and Cardiovascular disease. The Lancet Psychiatry. 2017; 4(4) :P320–329. doi:10.1016/S2215-0366(16)30377-7.
12. Karanikas E, Daskalakis NP, Agorastos A. Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review. Brain Sci. 2021; 11(6) :723. doi: 10.3390/brainsci11060723.
13. Koenen, K., Sumner, J., Gilsanz, P., Glymour, M., Ratanatharathorn, A., Rimm, E., et al. Post-traumatic stress disorder and cardiometabolic disease: Improving causal inference to inform practice. Psychological Medicine. 2017; 47(2) :209–225. doi:10.1017/S0033291716002294.
14. O’Donnell CJ, Longacre LS, Cohen BE, Fayad AA, Liberzon I, et al. Posttraumatic Stress Disorder and Cardiovascular Disease: State of the Science, Knowledge Gaps, and Research Opportunities. JAMA Cardiol. 2021; 6(10) :1207–1216. doi:10.1001/jamacardio.2021.2530.
15. Xue C, Ge Y, Tang B, Liu Y, Kang P, Wang M, et al. A Meta-Analysis of Risk Factors for Combat-Related PTSD among Military Personnel and Veterans. PLoS ONE. 2015; 10(3): e0120270. https://doi.org/10.1371/journal.pone.0120270.

Publication:

«World of Medicine and Biology» Vol. 18 No. 79 (2022) , с. 130-134
УДК 614.2:355.72:616.12-02

DOI:

https://doi.org/10.26724/2079-8334-2022-1-79-130-134